Muscle Cell News Volume 7.32 | Sep 19 2022

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    2022-09-19 | MUSCN 7.32


    Muscle Cell News by STEMCELL Technologies
    Vol. 7.32 – 19 September, 2022
    TOP STORY

    Impaired Dynamic Sarcoplasmic Reticulum Ca Buffering in Autosomal Dominant CPVT2

    Researchers explored variants of the CASQ2 gene that was found to be linked to Casq2-linked catecholaminergic polymorphic ventricular tachycardi (CPVT2) through mouse models and ventricular cardiomyocytes.
    [Circulation Research]

    AbstractGraphical Abstract
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    The Complement C3-Complement Factor D-C3a Receptor Signaling Axis Regulates Cardiac Remodeling in Right Ventricular Failure

    Scientists found that the right ventricle predominantly expressed alternative complement pathway-related genes, including Cfd and C3aR1, which was found to affect RV dysfunction and fibrosis.
    [Nature Communications]

    Full Article

    Biomimetic Cardiac Tissue Culture Model (CTCM) to Emulate Cardiac Physiology and Pathophysiology Ex Vivo

    Investigators developed a cardiac tissue culture model that could electro-mechanically stimulate heart slices with physiological stretches in systole and diastole during the cardiac cycle.
    [Communications Biology]

    Full Article

    Sirtuin 6 Inhibition Protects against Glucocorticoid-Induced Skeletal Muscle Atrophy by Regulating IGF/PI3K/AKT Signaling

    Researchers studied SIRT6, a chromatin-associated deacetylase, and its indirect influence in the regulation of glucocorticoid-induced muscle wasting by modulating IGF/PI3K/AKT signaling.
    [Nature Communications]

    Full Article

    Haploinsufficiency for CYP8B1 Associates with Increased Insulin Sensitivity in Humans

    By utilizing functional assays and sequencing CYP8B1 in individuals without diabetes, scientists were able to explore whether loss-of-function mutations in human muscle cells increased skeletal muscle insulin sensitivity, contributing to whole-body insulin sensitization.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    Loss of Cardiomyocyte CYB5R3 Impairs Redox Equilibrium and Causes Sudden Cardiac Death

    Investigators revealed that cytochrome b5 reductase 3 (CYB5R3) was essential for cardiomyocyte function. Using a conditional cardiomyocyte-specific CYB5R3-knockout mouse, they discovered that deletion of CYB5R3 in male, but not female, adult cardiomyocytes caused cardiac hypertrophy, bradycardia, and sudden cardiac death.
    [Journal of Clinical Investigation]

    Full Article

    Phosphatidylserine Orchestrates Myomerger Membrane Insertions to Drive Myoblast Fusion

    The authors revealed that Myomerger was regulated by movement of phosphatidylserine to the outer leaflet of membranes, which linked a well-known fusion-associated phenomenon to the myogenic fusion reaction.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Activation of SIRT1 Promotes Membrane Resealing via Cortactin

    Investigators explored the effects of resveratrol on membrane resealing within C2C12 cells via the activation of SIRT1. They performed membrane repair assays using C2C12 myoblasts, myotubes, and single fiber myotubes from mice to explore its capabilities as treatment for muscular dystrophies.
    [Scientific Reports]

    Full Article

    Iron Corroded Granules Inhibiting Vascular Smooth Muscle Cell Proliferation

    To investigate the effects of corroded granules on vascular smooth muscle cell proliferation, researchers implanted the corroded iron stent into the artery of the atherosclerotic artery stenosis model.
    [Materials Today Bio]

    Full ArticleGraphical Abstract

    FOXO1 Represses MCL1 Transcription to Regulate the Function of Vascular Smooth Muscle Cells in Intracranial Aneurysm

    Scientists investigated the role of FOXO1 in human brain vascular smooth muscle cells function via MCL1 expression and correlation analysis.
    [Experimental Brain Research]

    Abstract
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    REVIEWS

    Challenges and Opportunities for the Next Generation of Cardiovascular Tissue Engineering

    The authors provide a snapshot of the state-of-the-art methods in cardiac tissue engineering, with a focus on in vitro models of the human heart.
    [Nature Methods]

    Abstract

    Inflammatory Signaling in Atrial Cardiomyocytes: A Novel Unifying Principle in Atrial Fibrillation Pathophysiology

    Investigators consider therapeutic potentials and broader implications of this new knowledge and highlight crucial questions to be addressed in future research.
    [Nature Reviews Cardiology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Dyne Therapeutics Announces First Patient Dosed in Phase I/II DELIVER Clinical Trial of DYNE-251 for the Treatment of Duchenne Muscular Dystrophy

    Dyne Therapeutics, Inc. announced that the first patient has been dosed in its Phase I/II clinical trial, DELIVER, evaluating DYNE-251 for the treatment of Duchenne muscular dystrophy mutations amenable to exon 51 skipping.
    [Dyne Therapeutics, Inc.]

    Press Release

    BioJiva Reports Results of Pilot Phase II Clinical Trial of RT001 in Patients with Amyotrophic Lateral Sclerosis (ALS)

    BioJiva reported data from its completed multicenter, randomized, double-blind, placebo-controlled pilot Phase II clinical trial evaluating RT001, the company’s lead development candidate, in patients with ALS.
    [BioJiva (GlobeNewswire, Inc.)]

    Press Release
    FEATURED EVENT

    Cell Symposia: Multifaceted Mitochondria

    November 6 – 8, 2022
    Seville, Spain

    > See All Events

    JOB OPPORTUNITIES

    Research Associate – Skeletal Muscle Disease

    UC San Diego Health – San Diego, California, United States

    Postdoctoral Researcher – Muscle, Endothelial, and Hematopoietic Cells

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    PhD Position – Molecular Cell Biology & Genome Editing

    Leiden University Medical Center – Leiden, Netherlands

    PhD Positions – Vascular Biology and Aging

    USI – Bellinzona, Switzerland

    Postdoctoral Fellow – Genomics and Precision Medicine of Cardiomyopathies

    European Molecular Biology Laboratory – Heidelberg, Germany

    > See All Jobs

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