 | | Vol. 11.23 – 16 June, 2022 |
| |
|
|
| Scientists showed that Prevotella melaninogenica enhanced protection against Streptococcus pneumoniae, resulting in rapid pathogen clearance from the lung and improved survival in a mouse lung co-infection model.
[Nature Communications] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Cell compatibility, uptake, and intracellular trafficking were characterized in the murine alveolar macrophage cell line MH-S and the human bronchial epithelial cell line BEAS-2B in vitro.
[Small] |
|
|
|
| Investigators identified that signal transducer and activators of transduction 6 (STAT6) acted as a critical regulator of epithelium ferroptosis during acute lung injury.
[Cell Death & Disease] |
|
|
|
| Researchers generated lung bud organoids derived from human embryonic stem cells to study the interaction of Streptococcus pneumoniae with the alveolar epithelium.
[Microbiology Spectrum] |
|
|
|
| To examine the overall effect of STC1 on metabolism, scientists conducted a comprehensive metabolomics analysis to screen the overall metabolic changes induced by STC1 in an alveolar epithelial cell line.
[American Journal of Respiratory Cell and Molecular Biology] |
|
|
|
| Using Sendai virus to model natural infection in mice, investigators found evidence that alveolar type 1 cells had an intermediary role by persisting in areas depleted of alveolar type 2 cells, upregulating interferon responsive genes, and receding from invading airway cells.
[American Journal of Respiratory Cell and Molecular Biology] |
|
|
|
| Researchers evaluated the pharmacological activity of the ethanol extract of Veronica persica in an airway inflammation model.
[Biomedicine & Pharmacotherapy] |
|
|
|
| The authors investigated the mechanisms underlying the action of interleukin-6 neutralizing antibodies in attenuating airway mucus hypersecretion in COPD.
[Biomedicine & Pharmacotherapy] |
|
|
|
| Investigators assessed for changes in abundance and distribution of hemidesmosome-associated proteins following diacetyl (DA) exposure that contributed to DA-induced epithelial toxicity.
[Scientific Reports] |
| |
|
|
| In an unbiased functional genetic screen for radiosensitization targets in lung cancer, scientists identified syntaxin 18, a protein involved in retrograde vesicular transport between the Golgi apparatus and endoplasmic reticulum, as mediator of radioresistance.
[Cell Death & Disease] |
|
|
|
| Researchers reported monolayer cancer cell models wherein the human NSCLC cell line H2228 and pancreatic cancer cell line AsPC-1 could be reversibly induced to a quiescent state under hypoxic and serum-starved conditions.
[Scientific Reports] |
|
|
|
| Scientists identified unique metabolite-related gene signatures specific for lung adenocarcinoma and lung squamous cell carcinoma and key pathways aberrantly regulated at both transcriptional and metabolic levels.
[Cancer Medicine] |
|
|
|
| The functions of semaphorin 4B in lung adenocarcinoma cells were investigated by in vitro experiments, including CCK-8 and plate clone formation.
[BMC Cancer] |
|
|
|
|
| Investigators discuss changes in cell populations and gene expression, highlighting potential common features, such as alveolar cell epithelial injury and aberrant repair and monocyte-derived macrophage populations.
[Human Genomics] |
|
|
|
|
| Galecto, Inc. announced that the first patient has been enrolled in the Phase IIa GALLANT-1 trial. GALLANT-1 was designed to study the combination of GB1211, Galecto’s oral small molecule galectin-3 inhibitor, with Roche’s PD-L1 checkpoint inhibitor, atezolizumab, for the first-line treatment of NSCLC.
[Galecto, Inc.] |
|
|
|
|
| December 8 – 10, 2022
Los Angeles, California, United States |
|
|
|
|
|
| | Washington University School of Medicine – St. Louis, Missouri, United States |
|
|
|
| | University of Vermont – Burlington, Vermont, United States |
|
|
|
| | University of Pittsburgh School of Medicine – Pittsburgh, Pennsylvania, United States |
|
|
|
| | Temple University – Philadelphia, Pennsylvania, United States |
|
|
|
| | German Cancer Research Center in the Helmholtz Association – Heidelberg, Germany |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
