Pulmonary Cell News Volume 11.28 | Jul 21 2022

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    2022-07-21 | PULCN 11.28


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.28 – 21 July, 2022
    TOP STORY

    Interleukin-6–Dependent Epithelial Fluidization Initiates Fibrotic Lung Remodeling

    Through transcriptomic profiling and pharmacologic stimulation of epithelial cultures, scientists identified interleukin-6 signaling as a driver of tissue fluidization.
    [Science Translational Medicine]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    CRISPR Interference Interrogation of COPD GWAS Genes Reveals the Functional Significance of Desmoplakin in iPSC-Derived Alveolar Epithelial Cells

    The authors applied CRISPR interference to interrogate the function of nine genes implicated in COPD by genome-wide association studies in induced pluripotent stem cell–derived type 2 alveolar epithelial cells.
    [Science Advances]

    Abstract

    Mutant KRAS Regulates Transposable Element RNA and Innate Immunity via KRAB Zinc-Finger Genes

    Investigators analyzed the transcriptomes of human airway and bronchial epithelial cells transformed with mutant KRAS to define the landscape of KRAS-regulated noncoding RNAs.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Wood Smoke Particulate Matter (PM2.5) Induces Pyroptosis through Both Caspase-1/Il-1β/Il-18 and ATP/P2Y-Dependent Mechanisms in Human Bronchial Epithelial Cells

    Scientists investigated the underlying molecular mechanisms in how biofuel particulate matter (PM2.5) induced bronchial epithelial cell death and dysfunction.
    [Chemosphere]

    AbstractGraphical Abstract

    In Vitro Airway Models from Mice, Rhesus Macaques, and Humans Maintain Species Differences in Xenobiotic Metabolism and Cellular Responses to Naphthalene

    Researchers evaluated xenobiotic metabolism maintenance within differentiated air-liquid interface airway epithelial cell cultures, isolated airway epithelial cells, and ex vivo microdissected airways by measuring gene expression, glutathione content, and naphthalene metabolism.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    Melatonin Counteracts Necroptosis and Pulmonary Edema in Cadmium-Induced Chronic Lung Injury Through the Inhibition of Angiotensin II

    The authors identified the efficacy of melatonin to control the renin-angiotensin system in cadmium-induced chronic lung injury in a mouse model.
    [Journal of Biochemical and Molecular Toxicology]

    Abstract

    Arsenic Induces Bronchial Epithelial Carcinogenesis with Mitochondrial Dysfunction through AKAP95-Mediated Cell Cycle Alterations

    Researchers investigated how high and low doses of arsenic induced human bronchial epithelial cell transformation. Human bronchial epithelial cells were exposed to varying high-dose sodium arsenite for the short-term or treated with low-dose for the long-term.
    [Toxicology and Applied Pharmacology]

    AbstractGraphical Abstract

    Structural Basis and Molecular Mechanism of Biased GPBAR Signaling in Regulating NSCLC Cell Growth via YAP Activity

    The authors showed that different Gs/arrestin-biased signaling of G protein-coupled bile acid receptor (GPBAR) played key roles in NSCLC cell viability.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Cancer-Associated Fibroblast-Derived Exosomal MicroRNA-20a Suppresses the PTEN/PI3K-AKT Pathway to Promote the Progression and Chemoresistance of Non-Small Cell Lung Cancer

    Investigators explored the ability of microRNA-20a within cancer-associated fibroblast-derived exosomes to influence NSCLC progression.
    [Clinical and Translational Medicine]

    Full Article

    Activated Amino Acid Response Pathway Generates Apatinib Resistance by Reprograming Glutamine Metabolism in Non-Small-Cell Lung Cancer

    Scientists demonstrated that apatinib could reprogram glutamine metabolism in human NSCLC via a mechanism involved in amino acid metabolic imbalances.
    [Cell Death & Disease]

    Full Article

    Snail Acetylation by Autophagy-Derived Acetyl-Coenzyme a Promotes Invasion and Metastasis of KRAS-LKB1 Co-Mutated Lung Cancer Cells

    Researchers employed a liquid chromatography-based metabolomic approach that represented an autophagy/epithelial-to-mesenchymal transition (EMT)-coactivated invasive lung cancer subtype for the identification of metabolites linked to autophagy-driven EMT activation.
    [Cancer Communications]

    Full Article

    eEF-2K Knockdown Synergizes with STS Treatment to Inhibit Cell Proliferation, Migration, and Invasion via the TG2/ERK Pathway in A549 Cells

    The authors investigated the roles of sodium tanshinone IIA sulfonate (STS) and elongation factor-2 kinase (eEF-2K) in regulating the proliferation, migration, and invasion of A549 cells and explored the implicated pathways.
    [Journal of Biochemical and Molecular Toxicology]

    Abstract

    Grow Functional Airway Organoids with PneumaCult™
    REVIEWS

    Human Lung Organoids as a Model for Respiratory Virus Replication and Countermeasure Performance in Human Hosts

    Human organoid models provide a platform to study virus-host interactions in the proximal to distal lung in the absence of a human in vivo model.
    [Translational Research]

    Full Article

    Nanocarrier-Based Approaches to Combat Chronic Obstructive Pulmonary Disease

    Scientists provide updated information about the treatment of COPD along with nanocarrier-based approaches, as well as the potential of gene therapy and stem cell therapy to combat COPD.
    [Nanomedicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    Algernon Pharmaceuticals Hits Co-Primary Endpoint in its Phase II Study of Ifenprodil for Idiopathic Pulmonary Fibrosis and Chronic Cough

    Algernon Pharmaceuticals, Inc. announced positive topline data showing that it has met the co-primary endpoint in its Phase II proof of concept study evaluating NP-120 for the potential treatment of idiopathic pulmonary fibrosis and chronic cough.
    [Algernon Pharmaceuticals, Inc. (Globe Newswire, Inc.)]

    Press Release

    Daewoong Pharmaceutical Gets First Korean US FDA Fast-Track for New Idiopathic Pulmonary Fibrosis Drug

    As many Korean pharmaceutical manufacturers are currently attempting to develop new drugs for idiopathic pulmonary fibrosis, Daewoong Pharmaceutical’s new medication DWN12088 has been fast-tracked by the US FDA, the first time a Korean pharma company has been awarded this status.
    [Daewoong Pharmaceutical Co., Ltd (Cision US, Inc.)]

    Press Release

    FEATURED EVENT

    The Lung Epithelium Conference: In Health and Disease

    Aug 7 – 12, 2022
    Saxtons River, Vermont, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Computational Approaches Focused on the Lung Microbiome

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Postdoctoral Scholar – Protein Degradation in Cancer and Alzheimer’s

    Virginia Commonwealth University – Richmond, Virginia, United States

    Postdoctoral Researcher – Brain Metastasis from Lung and Breast Cancers

    Hershey College of Medicine – Hershey, Pennsylvania, United States

    Associate Professor – Thematic Research Programs

    The Chinese University of Hong Kong – Hong Kong, China

    Postdoctoral Fellow – Thoracic Malignancies

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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