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pH and ROS Dual-Responsive Autocatalytic Release System Potentiates Immunotherapy of Colorectal Cancer

[Advanced Materials] A pH and reactive oxygen species (ROS) dual-responsive autocatalytic release system was constructed to reverse the immunosuppressive microenvironment and potentiate colorectal cancer immunotherapy.

Researchers Receive Grant to Boost Colorectal Cancer Screening Follow-Up in Underserved Communities

[UCLA Health] Researchers from the University of California, Los Angeles (UCLA) Health Jonsson Comprehensive Cancer Center were awarded a $3 million grant from the National Institutes of Health to improve follow-up care for colorectal cancer screening in underserved populations.

Abivax Announces First Patient Enrolled in ENHANCE-CD, the Phase IIb Trial of Obefazimod in Crohn’s Disease

[Abivax] Abivax SA announced the first patient was enrolled in its Phase IIb ENHANCE-CD trial evaluating obefazimod in patients with Crohn’s disease.

LSD1 and CoREST2 Potentiate STAT3 Activity to Promote Enteroendocrine Cell Differentiation in Mucinous Colorectal Cancer

[Cancer Research] Single cell multi-omics uncovered epigenetic alterations that accompany enteroendocrine cells (EEC) differentiation, identified STAT3 as a regulator of EEC specification, and discovered a rare cancer-specific cell type with enteric neuron-like characteristics.

World-First Therapy Using Donor Cells Sends Autoimmune Diseases into Remission

[Nature News] One woman and two men with severe autoimmune conditions have gone into remission after being treated with bioengineered and CRISPR-modified immune cells1. The three individuals from China are the first people with autoimmune disorders to be treated with engineered immune cells created from donor cells, rather than ones collected from their own bodies.

Mechanical Strategies to Promote Vascularization for Tissue Engineering and Regenerative Medicine

[Burns & Trauma] Scientists summarizes the influence and contribution of both scaffold-based and external stimulus-based mechanical strategies for vascularization in tissue engineering and elucidates the underlying mechanisms involved.

CD56-Targeted In Vivo Genetic Engineering of Natural Killer Cells Mediates Immunotherapy for Acute Myeloid Leukemia

[Nanoscale] In vivo CD56+ NK cell genetic engineering is hypothesized through the CD56-directed delivery of the pSMP-EzH2 shRNA plasmid encapsulated in chitosan nanoparticles.

Curium Announces Strategic Partnership with PeptiDream for Prostate Cancer Theranostics in Japan

[Curium] Curium announced that it has entered into a strategic partnership with PDRadiopharma, Inc, a wholly-owned subsidiary of PeptiDream, for the clinical development, regulatory filing, and commercialization in Japan of 177Lu-PSMA-I&T and 64Cu-PSMA-I&T.

UK Black Men Are 2.5 Times As Likely To Die From Prostate Cancer

[Forbes] A “dangerously biased” combination of social factors and inadequate research is raising Black men’s already-heightened risk of developing prostate cancer, a UK charity has stated

Evaluating 4Kscore’s Role in Predicting Progression on Active Surveillance for Prostate Cancer Independently of Clinical Information and PIRADS Score

[Prostate Cancer and Prostatic Diseases] This was a single-institution, single-arm, non-therapeutic, interventional trial of 166 men with biopsy-confirmed prostate cancer enrolled between 2014–2020. Patients were placed on a trial-mandated AS protocol including yearly multiparametric MRI, prostate biopsy, and 4Kscore followed for 48 months after diagnosis.

PDIA2 Is Associated with the Prognosis of Prostate Cancer, and Downregulation of PDIA2 Delays the Progression of Prostate Cancer Cells

[Scientific Reports] Patients with prostate cancer who express PDIA2 high in particular have a bad prognosis in terms of progression-free survival. In addition, the upregulation of PDIA2 expression in prostate cancer patients was accompanied by higher Gleason scores, advanced tumor staging, lymph node metastasis, and elevated PSA levels.

Proinflammatory Immune Cells Disrupt Angiogenesis and Promote Germinal Matrix Hemorrhage in Prenatal Human Brain

[Nature Neuroscience] Researchers showed that microglia in prenatal mouse and human brain interact with nascent vasculature in an age-dependent manner and that ablation of these cells in mice reduced angiogenesis in the ganglionic eminences, which corresponded to the human germinal matrix.
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