Impaired Immunosuppressive Role of Myeloid-Derived Suppressor Cells in Acquired Aplastic Anemia

[Haematologica] Myeloid-derived suppressor cells (MDSCs) populations were evaluated in acquired aplastic anemia in which aberrant immune mechanisms contributed to bone marrow destruction.

Ellagic Acid Improves Benign Prostate Hyperplasia by Regulating Androgen Signaling and STAT3

[Cell Death & Disease] To investigate the effect of ellagic acid (EA) on benign prostate hyperplasia, scientists used EA, a phytochemical abundant in fruits and vegetables, to treat testosterone propionate-induced BPH rats and RWPE-1 human prostate epithelial cells.

Identification of Prostate Cancer Subtypes Based on Immune Signature Scores in Bulk and Single-Cell Transcriptomes

[Medical Oncology] Researchers identified two prostate cancer (PC) subtypes: PC immunity high and PC immunity low, consistently in these datasets.

Leptin Modulated MicroRNA-628-5p Targets Jagged-1 and Inhibits Prostate Cancer Hallmarks

[Scientific Reports] Investigators examined the detailed cellular phenotypes and pathways regulated by miR-628 in prostate cancer cells.

Hippo Pathway Monomerizes STAT3 to Regulate Prostate Cancer Growth

[Cancer Science] Scientists showed that high cell density-mediated activation of Hippo pathway blunted STAT3 activity in prostate cancer cells.

CKAP2L, a Crucial Target of miR-326, Promotes Prostate Cancer Progression

[BMC Cancer] CKAP2L expression was examined in the normal and tumor tissues of prostate cancer patients with RT-QPCR and Western blot.

Dual STAT-3 and IL-6R Inhibition with Stattic and Tocilizumab Decreases Migration, Invasion and Proliferation of Prostate Cancer Cells by Targeting the IL-6/IL-6R/STAT-3 Axis

[Oncology Reports] Researchers investigated the effect of Stattic + Tocilizumab on proliferative, clonogenic, migratory and invasive ability of human metastatic prostate cancer, as assessed by colony formation, wound healing and migration assay.

$3.5M Study to Better Predict Prostate Cancer Risk

[University of Hawai'i News] To increase public understanding of the causes of prostate cancer, the University of Hawaiʻi Cancer Center will lead a $3.5 million public impact research study to further our understanding of prostate cancer to improve prediction of future disease.

Lymphatics Act as a Signaling Hub To Regulate Intestinal Stem Cell Activity

[Cell Stem Cell] Employing in vivo loss of function and lymphatic:organoid cocultures, researchers showed that crypt lymphatics maintained intestinal stem cells and inhibited their precocious differentiation.

Human 2D Crypt Model for Assaying Intestinal Stem Cell Proliferation and Differentiation

[Analytical Chemistry] A planar, self-renewing human intestinal monolayer platform based on primary adult gastrointestinal stem cells, termed the 2D crypt model, was developed to screen for the effects of various compounds on the intestinal epithelium.

Hederacoside C Ameliorates Colitis via Restoring Impaired Intestinal Barrier Through Moderating S100A9/MAPK and Neutrophil Recruitment Inactivation

[Acta Pharmacologica Sinica] The authors investigated how HSC attenuated intestinal inflammation in vivo and in vitro.

Chicken-Derived RSPO1 and WNT3 Contribute to Maintaining Longevity of Chicken Intestinal Organoid Cultures

[Scientific Reports] Based on the limited homology between mammalian and avian RSPO1, scientists expected that chicken-derived factors were required for the organoid cultures.