Newsletters

[Cell Death & Differentiation] The authors discovered that highly expressed PSMD14 strengthens tumor stemness and drives tumor progression by increasing glycolysis and lactate accumulation, which activates H3K27 lactylation and turns to enhance the expression of PSMD14 and SOX9.

[Cell Reports] Investigators identified a function for the microprotein FXYD domain-containing transport regulator 3 (FXYD3) in goblet cells in regulating mucus layer formation to maintain intestinal homeostasis.

[Cell Death & Disease] Researchers demonstrated that JMJD3 is highly expressed in both gastric cancer tissues and patient-derived chemotherapy-resistant xenograft models and contributes to increased malignancy and chemoresistance.

[Cell Death & Disease] Scientists integrated single-cell RNA sequencing of primary tumors and matched metastatic lymph nodes from six gastric cancer patients to identify a metastatic epithelial subpopulation characterized by early growth response (EGR) 4 overexpression.

[Stem Cell Research & Therapy] The authors examined the role of L-glutamate in regulating cell mitochondrial biosynthesis using in vivo piglets, ex vivo porcine intestinal organoids, and in vitro IPEC-J2 cells.

[Stem Cell Research & Therapy] Intestinal epithelium specific conditional cystathionine-β-synthase (CBS) knockout mice were generated by crossing CBS^fl/+ mice with Villin-CreERT2 mice.

[Oncogenesis] Researchers demonstrated that nuclear factor of activated T-cells c1 (NFATc1) enhances NAD kinase expression, elevating intracellular NADP+ levels to activate the pentose phosphate pathway, thereby boosting proliferation.

[International Journal of Oncology] Scientists identified key regulators of ferroptosis at distinct pathological stages, thereby providing insight of novel strategies for the management of precancerous lesion‑related diseases and gastric cancer.

[Wellcome Sanger Institute] Professor Sir Mike Stratton and Dr Trevor Lawley, together with Dr Paul Brennan have been awarded a €10.4 million grant, enabling their team to investigate the causes of early onset colorectal cancer.

[UMass Chan Medical School] UMass Chan Medical School PhD candidate Katherine Murphy has received a Ruth L. Kirschstein National Research Service Award Individual Predoctoral Fellowship for her prostate cancer research in the lab of Marcus Ruscetti, PhD, assistant professor of molecular, cell & cancer biology.

[University of Wisconsin–Madison] A five-year, $12.5 million grant has been awarded to researchers at University of Wisconsin–Madison to investigate metastatic, or advanced stage, prostate cancer, the second most common cause of cancer death in men.

[Current Urology Reports] The authors summarize the applications of CAR cell therapy in the following 3 major urological tumors: renal cell carcinoma, bladder cancer, and prostate cancer.