Research Progress on the Immunological Functions of Piezo1 a Receptor Molecule That Responds to Mechanical Force

[International Immunopharmacology] The authors explore the physiological functions and regulatory mechanisms of Piezo1 and its impact on innate and adaptive immunity. This may offer new insights into diagnostics and therapeutics for the prevention and treatment of diseases and surgical infections.

The Role of Chimeric Antigen Receptor T Cell Therapy in Immune-Mediated Neurological Diseases

[Annals of Neurology] Scientists present the state-of-the-art and future directions of the use of CAR-T in immune-mediated neurological dieases

Epidermal Growth Factor-Like Domain 7 Drives Brain Lymphatic Endothelial Cell Development through Integrin αvβ3

[Nature Communications] Researchers showed that Egfl7 was expressed in both blood and lymphatic endothelial cells. They generate an egfl7cq180 mutant with a 13-bp-deletion in exon 3 leading to reduced expression of Egfl7.

The BCR::ABL1 Tyrosine Kinase Inhibitors Ponatinib and Nilotinib Differentially Affect Endothelial Angiogenesis and signaling

[Molecular and Cellular Biochemistry] Scientists investigated the effects of three BCR::ABL1 inhibitors, ponatinib, nilotinib and imatinib, on angiogenesis and signaling in human endothelial cells in response to vascular endothelial growth factor.

First Patient Dosed in Phase III Gliofocus Study for Newly Diagnosed Glioblastoma Patients at the Ivy Brain Tumor Center

[Ivy Brain Tumor Center] The Ivy Brain Tumor Center at Barrow Neurological Institute announced that the first patient has been dosed in the Phase III Gliofocus Study. Gliofocus is an open-label, randomized Phase III trial that will compare the efficacy of niraparib, a PARP1/2 selective inhibitor, to temozolomide head-to-head in adult patients with newly diagnosed MGMT-unmethylated glioblastoma.

Novel Immunomodulatory Properties of Adenosine Analogs Promote Their Antiviral Activity Against SARS-CoV-2

[EMBO Reports] In the case of remdesivir, investigators showed that immunomodulatory properties are due to its metabolite, GS-441524, acting as an adenosine A2A receptor antagonist. Their findings supported a new rationale for the design of next-generation antiviral agents with dual - immunomodulatory and intrinsic - antiviral properties.

In Vitro and In Vivo Inhibition of the Host TRPC4 Channel Attenuates Zika Virus Infection

[EMBO Molecular Medicine] Researchers investigated whether TRPCs might be involved in the pathogenesis of Zika virus (ZIKV) infection. They found that ZIKV infection increases TRPC4 expression in host cells via the interaction between the ZIKV-NS3 protein and CaMKII, enhancing TRPC4-mediated calcium influx.

A Novel Murine Model Mimicking Male Genital Neisseria Species Infection Using Neisseria musculi

[Biology of Reproduction] Scientists inoculated mice via the intrapenile route with N. musculi. THey assessed bacterial burden throughout the male reproductive tract, the systemic and tissue-specific immune response two weeks postinfection, and the effect of infection on sperm health.

Specific CD4+ T Cell Phenotypes Associate with Bacterial Control in People Who ‘Resist’ Infection with Mycobacterium tuberculosis

[Nature Immunology] Researchers found that Mtb-specific T cells in resisters (RSTR) were clonally expanded, confirming the priming of adaptive immune responses following Mtb exposure. RSTR CD4+ T cells showed enrichment of TH17 and regulatory T cell-like functional programs compared to Mtb-specific T cells from individuals with latent Mtb infection.

Acquired Epidermodysplasia Verruciformis Syndrome in HIV-Infected Patients: A Systematic Review

[Archives of Dermatological Research] Congenital epidermodysplasia verruciformis is a Genodermatosis linked to different inheritance patterns and mutations of the EVER1/TMC6 and EVER2/TMC8 genes. There is an acquired form (AEV) associated with immunodeficiency states, including HIV infection; however, the literature about AEV is limited and imprecise.

Bird Flu Could Become a Human Pandemic. How Are Countries Preparing?

[Nature] As cases of avian influenza continue to rise in cattle in the United States, countries are preparing for the possibility that the virus could start spreading in people. Many nations are ramping up surveillance, as well as purchasing vaccines or developing new ones.

Microbiologist Wins Case Against University over Harassment during COVID

[Nature] A New Zealand court has ruled that the University of Auckland breached its obligations to protect high-profile microbiologist Siouxsie Wiles from the intense abuse and harassment she experienced while providing public information about the COVID-19 pandemic.