Newsletters

Autophagy Regulates the Maturation of Hematopoietic Precursors in the Embryo

[Nature Communications] Using combined approaches, including scRNA-seq, researchers confirmed that autophagy-related gene 5 deletion interrupted developmental temporal order of endothelial to hematopoietic transition to further affect the pre-HSC I maturation.

Malignant Progression of Pre-Leukemic Disorders

[Blood] Scientists review the mechanisms of progression focusing on the hierarchy of clonal mutation and potential roles of transcription factor alterations, splicing factor mutations, and the bone marrow environment in progression to AML.

Alterations in Exocrine Pancreatic Function after Acute Pancreatitis

[Pancreatology] Investigators discuss the epidemiology, pathophysiology, and clinical management of exocrine pancreatic dysfunction after acute pancreatitis while highlighting key knowledge gaps.

Genprex Receives Notice of Patent Grant for Korean Patent Claiming Reqorsa® Immunogene Therapy with PD-1 and PD-L1 Antibodies to Treat Cancers

[Genprex Inc.] Genprex, Inc. announced that the Korean Patent Office has issued a Notice of Patent Grant for a broad patent that covers the use of Genprex’s lead drug candidate, Reqorsa® Immunogene Therapy.

Txnip Regulates the Oct4-Mediated Pluripotency Circuitry via Metabolic Changes upon Differentiation

[Cellular and Molecular Life Sciences] Researchers revealed the novel functions of mouse Txnip in cellular reprogramming and differentiation onset by involving in glucose-mediated histone acetylation and the regulation of Oct4, which was a fundamental component of the molecular circuitry underlying pluripotency.

Microglial Over-Pruning of Synapses during Development in Autism-Associated SCN2A-Deficient Mice and Human Cerebral Organoids

[Molecular Psychiatry] Scientists reported that Scn2a-deficient mice had impaired learning and memory, accompanied by reduced synaptic transmission and lower spine density in neurons of the hippocampus.

YTHDF1-CLOCK Axis Contributes to Pathogenesis of Allergic Airway Inflammation through LLPS

[Cell Reports] Scientists reported that YTHDF1 was highly expressed in allergic airway epithelial cells and asthmatic patients and that it influenced proinflammatory responses.

CPT1A Mediates the Succinylation of SP5 Which Activates Transcription of PDPK1 to Promote the Viability and Glycolysis of Prostate Cancer Cells

[Cancer Biology & Therapy] The authors investigated the role of carnitine palmitoyltransferase 1A (CPT1A), which was a succinyltransferase in the progression of prostate cancer. CCK-8 was used to detect the cell viability.

Revolutionizing Pancreatic Islet Organoid Transplants: Improving Engraftment and Exploring Future Frontiers

[Life Sciences] Hypoxia-induced necrosis and delayed revascularization attenuate organoid viability and functional capacity, alleviated by the integration of diverse cell types e.g., human amniotic epithelial cells and human umbilical vein endothelial cells to boost vascularization.

Comparison Between Stem Cell Therapy and Stem Cell Derived Exosomes on Induced Multiple Sclerosis in Dogs

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Dog models of multiple sclerosis received either a single treatment of stem cells or a single treatment of exosomes intrathecally and the treatment process was evaluated clinically, radiologically, histopathologically, and electron microscopy and cerebrospinal fluid analysis.

Combined Transplantation of hiPSC-NSC and hMSC Ameliorated Neuroinflammation and Promoted Neuroregeneration in Acute Spinal Cord Injury

[Current Stem Cell Research & Therapy] To evaluate the therapeutic effects of combination cells, acute spinal cord injury mice model were established and combined transplantation of hiPSC-neural stem cells and human mesenchymal stem cells into the lesion site immediately after the injury.

Deformable Smart DNA Nanomachine for Synergistic Intracellular Cancer-Related miRNAs Imaging and Chemo-Gene Therapy of Drug-Resistant Tumors

[Small] Deformable smart DNA nanomachines were developed for synergistic intracellular cancer-related miRNAs imaging and chemo-gene therapy of drug-resistant tumors.
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