Endocrinology of the Aging Prostate: Current Concepts

[Frontiers In Endocrinology] Scientists systematically review the impact of hormonal changes that occur during aging on the prostate, including the role of sex hormones, insulin-like growth factor 1, thyroid hormones, and insulin.

Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway

[Research] Gradient rotating magnetic field exposure had a notable impact on the F-actin arrangement of MDA-MB-231, BT-549, and MDA-MB-468 cells, inhibiting cell migration and invasion.

LINC00460-FUS-MYC Feedback Loop Drives Breast Cancer Metastasis and Doxorubicin Resistance

[Oncogene] LINC00460 was demonstrated to promote stem cell-like and epithelial-mesenchymal transition characteristics in breast cancer cells.

Characterization of KIF20B as a Novel Prognostic Biomarker and Therapeutic Target for Breast Cancer

[International Journal of Oncology] Using reverse transcription‑quantitative PCR and western blotting, investigators discovered that kinesin family member 20B (KIF20B) mRNA and protein expression levels were upregulated in most breast cancer cell lines but were scarcely expressed in normal mammary epithelial cells.

Acetyl-CoA Carboxylase 1 Controls a Lipid Droplet–Peroxisome Axis and Is a Vulnerability of Endocrine-Resistant ER+ Breast Cancer

[Science Translational Medicine] Functional metabolic analysis revealed that lipid droplets together with peroxisomes, which researchers showed to be enriched and active in the long-term estrogen-deprived cells, controlled redox homeostasis and conferred metabolic adaptability to the resistant tumors.

Intestinal Stem Cells: Guardians of Homeostasis in Health and Aging amid Environmental Challenges

[Experimental & Molecular Medicine] The authors explore the regulatory mechanisms that govern intestinal stem cell behavior, emphasizing the dynamic adaptability of the intestinal epithelium in the face of various challenges.

Small Molecules That Disrupt RAD54-BLM Interaction Hamper Tumor Proliferation in Colon Cancer Chemoresistance Models

[Journal Of Clinical Investigation] Chromatin immunoprecipitation sequencing analysis and validation revealed increased BLM/RAD54 co-recruitment on MRP2 promoter in camptothecin resistant colon cancer cells, leading to BLM-dependent enhancement of RAD54-mediated chromatin remodelling.

AMBRA1 Promotes Intestinal Inflammation by Antagonizing PP4R1/PP4c Mediated IKK Dephosphorylation in an Autophagy-Independent Manner

[Cell Death & Differentiation] Investigators found that autophagy/beclin-1 regulator 1 (AMBRA1) was highly expressed in inflamed colons in a colitis mouse model and in clinical inflammatory bowel disease samples.

BCL-XL Inhibitors Enhance the Apoptotic Efficacy of BRAF Inhibitors in BRAFV600E Colorectal Cancer

[Cell Death & Disease] Scientists discovered that BRAFV600E colorectal cancers (CRC) expressed high basal levels of the pro-survival proteins MCL-1 and BCL-XL, and that combining encorafenib with a BCL-XL inhibitor significantly enhanced apoptosis in BRAFV600E CRC cell lines.

PIKFYVE Inhibitors Trigger Interleukin-24-Dependent Cell Death of Autophagy-Dependent Melanoma

[Molecular Oncology] Autophagy-dependent melanoma cells were compared with normal foreskin fibroblasts to elucidate the mechanism by which 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE) inhibition induces cell death.

Modifying miRs for Effective Reprogramming of Fibroblasts to Cardiomyocytes

[Molecular Therapy - Nucleic Acids] Researchers reported enhanced efficacy of our miR reprogramming cocktail miR combo, miR-1, miR-133a, miR-208a and miR-499, via RNA-sensing receptor stimulation.

MBNL1 Regulates Programmed Postnatal Switching between Regenerative and Differentiated Cardiac States

[Circulation] Muscleblind-like 1 (MBNL1) gain- and loss-of-function mouse models were studied at several developmental time points and in surgical models of heart regeneration.