Newsletters

[International Journal of Stem Cells] Mice and human umbilical vein endothelial cell models did not sufficiently elucidate the relationship between the genotype and disease phenotype in hereditary hemorrhagic telangiectasia 1, demanding more clinically relevant models that reflect human genetics. Therefore, the authors used prime editing to propose a method for establishing an isogenic hiPSC line.

[Stem Cell Research] Researchers introduced the RS1 (c.C304T, p.R102W) mutation into a normal iPSC line using CRISPR/Cas9 technology.

[Scientific Reports] Using hESC lines, scientists modeled MECP2 loss-of-function to explore its effects on astrocyte development and dysfunction in the brain.

[Cellular and Molecular Life Sciences] Investigators presented a genetically encoded fluorescent probe used to track changes in H3K9me3 landscapes during the differentiation of iPSCs into induced neurons.

[Experimental Hematology] iPSCs hold the potential to address challenges with utilizing adoptive cell therapy as cancer treatment, as they can provide an unlimited source for the in vitro generation of immune cells.

[FUJIFILM Cellular Dynamics] FUJIFILM Cellular Dynamics announced the global commercial launch of its human iPSC-derived iCell® Sensory Neurons for scientists engaged in neuroscience research, drug discovery of novel pain medications, and analysis of neurotoxicity side effects.

[Nature Neuroscience] Researchers reported that continuous oligodendroglial lipid metabolism provided an energy reserve in white matter tracts.

[Advanced Materials] The authors introduced a polyethylene glycol-based hydrogel model. The effects of 4D-triggered network mechanical changes on human mesenchymal stem cell morphology and Hippo signaling, as well as Caco-2 colorectal cancer cell mechanomemory using transcriptomics and metabolic assays were investigated.

[Cancer Research] Through analyses of single-cell sequencing data, investigators identified a population of cancer-associated fibroblasts expressing high levels of sulfatase 1 (SULF1), which was associated with poor prognosis in colorectal cancer (CRC) patients.

[EMBO Reports] Scientists demonstrated that targeting a small subset of neurons with a combined overexpression of neuropeptide Y and Y2 receptor was sufficient to reduce the occurrence of spontaneous seizures.

[Advanced Healthcare Materials] Scientists constructed a biomimetic material system comprising gelatin, alginate, and fibrinogen for neural progenitor cell constructs using 3D printing, which exhibited excellent formability, stability, and developmental functions in vitro, as well as biocompatibility and integration into the hippocampus in vivo.

[Translational Psychiatry] Scientists explore the role of specific miRNAs in Alzheimer’s disease progression, focusing on their impact on β-amyloid peptide accumulation, intracellular aggregation of hyperphosphorylated tau proteins, mitochondrial dysfunction, neuroinflammation, oxidative stress, and the expression of the APOE4 gene.