Newsletters

Tumor Organoid-Immune Co-Culture Models: Exploring a New Perspective of Tumor Immunity

[Cell Death Discovery] Investigators discuss the progress achieved in co-culturing tumor organoids with immune cells.

Transcriptional Regulation by PHGDH Drives Amyloid Pathology in Alzheimer’S Disease

[Cell] Researchers showed that altered expression of the late-onset Alzheimer's disease (AD) biomarker phosphoglycerate dehydrogenase (PHGDH) modulates AD pathology in mice and human brain organoids independent of its enzymatic activity.

Human iPS Cell-Derived Respiratory Organoids As a Model for Respiratory Syncytial Virus Infection

[Life Science Alliance] The authors evaluated hiPSC-derived respiratory organoids, which contained respiratory epithelial cells, immune cells, fibroblasts, and vascular endothelial cells, for their potential to model respiratory syncytial virus infection and support pharmaceutical research.

Engineering Neuronal Networks in Granular Microgels to Innervate Bioprinted Cancer Organoids On-a-Chip

[Lab On A Chip] Researchers presented a versatile organ-on-a-chip platform designed to innervate organoids across diverse tissue types.

Loss of Intracellular ATP Affects Axoplasmic Viscosity and Pathological Protein Aggregation in Mammalian Neurons

[Science Advances] The authors showed that intracellular adenosine triphosphate (ATP) regulated axoplasmic viscosity and protein aggregation in mammalian neurons.

Synaptophysin Accelerates Synaptic Vesicle Fusion by Expanding the Membrane upon Neurotransmitter Loading

[Science Advances] Researchers showed that during transmitter loading, synaptic vesicles substantially increased in size, which was reversible and required synaptophysin, an abundant membrane protein with an unclear function.

Novel Humanized CD19-CAR-T (Now Talicabtagene Autoleucel, Tali-Celâ„¢) Cells in Relapsed/ Refractory Pediatric B-Acute Lymphoblastic leukemia- an Open-Label Single-Arm Phase-I/Ib Study

[Blood Cancer Journal] Investigators developed a novel humanized CD19-directed CAR-T approved for Phase I/Ib/II trials. Patients aged 3–25 years were enrolled with relapsed/refractory B-acute lymphoblastic leukemia and ineligible for allogeneic stem cell transplant.

In Vivo Functional Screens Reveal KEAP1 Loss As a Driver of Chemoresistance in Small Cell Lung Cancer

[Science Advances] As small cell lung cancer patient-derived xenograft (PDX) models mimic therapeutic responses, scientists performed genetic screens in chemosensitive PDX models to identify drivers of chemoresistance.

Fangchinoline-Mediated Autophagy Inhibition Amplifies Antigen Presentation and PD-1 Blockade Efficacy in Lung Cancer

[Acta Pharmacologica Sinica] Researchers investigated the modulatory effects of PD-1 blockade combined with fangchinoline on CD8+ T cells within the tumor microenvironment of lung cancer.

Spatial Mapping of Transcriptomic Plasticity in Metastatic Pancreatic Cancer

[Nature] Researchers constructed high-resolution maps of lineage states, clonal architecture, and the tumor microenvironment using spatially resolved transcriptomics from 55 samples of primary tumor and metastases collected from rapid autopsies of 13 people.

Endothelial Piezo1 Stimulates Angiogenesis to Offer Protection against Intestinal Ischemia-Reperfusion Injury in Mice

[Molecular Medicine] Investigators explored the specific roles and underlying mechanisms by which endothelial Piezo1 was involved in intestinal ischemia–reperfusion injury.

BMAL1-HIF2A Heterodimer Modulates Circadian Variations of Myocardial Injury

[Nature] Investigators showed that the core circadian transcription factor BMAL1 regulated circadian-dependent myocardial injury by forming a transcriptionally active heterodimer with a non-canonical partner, hypoxia-inducible factor 2 alpha (HIF2A), in a diurnal manner.
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