SMYD2-Methylated PPARγ Facilitates Hypoxia-Induced Pulmonary Hypertension by Activating Mitophagy

[Circulation Research] Pulmonary hypertension (PH) animal models were generated by treating mice/rats with chronic hypoxia for four weeks. SMYD2-vTg mice or wild-type rats and mice treated with LLY-507 were used to investigate the function of suppressor of variegation, enhancer of zeste, trithorax and myeloid Nervy DEAF-1 domain-containing protein 2 (SMYD2) on PH development in vivo.

PI3K/HSCB Axis Facilitates FOG1 Nuclear Translocation to Promote Erythropoiesis and Megakaryopoiesis

[eLife] Investigators identified heat shock cognate B as an indispensable protein for friend of GATA 1 (FOG1) nuclear translocation during erythropoiesis of K562 human erythroleukemia cells and cord-blood-derived human CD34+CD90+HSCs, as well as during megakaryopoiesis of the CD34+CD90+HSCs.

EVIDENCE Meta-Analysis: Evaluating Minimal Residual Disease as an Intermediate Clinical Endpoint for Multiple Myeloma

[Blood] This meta-analysis was based on the FDA guidance for considerations for a meta-analysis of minimal residual disease (MRD) as a clinical endpoint and evaluates MRD-negativity as an early endpoint reasonably likely to predict long-term clinical benefit.

RUNX1 C-terminal Mutations Impair Blood Cell Differentiation by Perturbing Specific Enhancer-Promoter Networks

[Blood Advances] Researchers characterized RUNX1 mutations outside of the runt homology domain. Their analysis of the patient data sets revealed that mutations within the C-terminus frequently occur in hematopoietic disorders.

BRG1/BRM Inhibitor Targets AML Stem Cells and Exerts Superior Preclinical Efficacy Combined with BET or Menin Inhibitor

[Blood] Investigators showed that FHD-286 induced differentiation and lethality in AML cells with MLL1 rearrangement or mutant NPM1, concomitantly causing perturbed chromatin accessibility and repression of c-Myc, PU.1, and CDK4/6.

The Glutaminase Inhibitor CB-839 Targets Metabolic Dependencies of JAK2-Mutant Hematopoiesis in MPN

[Blood Advances] Scientists showed that CB-839 strongly reduced the mitochondrial respiration rate of bone marrow cells from JAK2-V617F mutant mice, demonstrating a marked dependence of these cells on glutamine-derived ATP production.

SDHAF1 Confers Metabolic Resilience to Aging Hematopoietic Stem Cells by Promoting Mitochondrial ATP Production

[Cell Stem Cell] Researchers reported that HSCs acquired metabolic resilience that promoted cell survival. High-resolution real-time ATP analysis with glucose tracing and metabolic flux analysis revealed that old HSCs reprogrammed their metabolism to activate the pentose phosphate pathway.

Biological Relevance of Alternative Splicing in Hematologic Malignancies

[Molecular Medicine] Investigators provide an extensive overview of the biological relevance of aberrant isoforms of genes involved in the regulation of apoptosis, activation of key cellular signaling pathways, and cell metabolism.

DiPersio Receives Innovation Award

[Washington University School of Medicine in St. Loui] John F. DiPersio has received the Chancellor’s Award for Innovation and Entrepreneurship for his research contributions to the field of oncology that are paving the way for novel cancer therapies.

Mesenchymal Stromal Cells Protect Tissues from Th1 Immune Responses via IL-11 Secretion

[FASEB Journal] In vitro culture assays demonstrated that MSCs suppressed the activation and function of CD4+ T cells by secreting interleukin 11, and neutralization of IL11 abrogated MSC-mediated suppression of CD4+ T cell function.

HMGA1 Regulates Trabectedin Sensitivity in Advanced Soft-Tissue Sarcoma (STS): A Spanish Group for Research on Sarcomas (GEIS) Study

[Cellular and Molecular Life Sciences] The prognostic/predictive value of HMGA1 expression was assessed in a cohort of 301 STS patients at mRNA and protein level, by HTG EdgeSeq transcriptomics and immunohistochemistry, respectively.

Lineage-Specific Mesenchymal Stromal Cells Derived from Human iPSCs Showed Distinct Patterns in Transcriptomic Profile and Extracellular Vesicle Production

[Advanced Science] A stepwise human induced pluripotent stem cells-to-MSCs differentiation method was employed via intermediate cell stages of neural crest and cytotrophoblast to generate lineage-specific MSCs with varying differentiation efficiencies and gene expression.