Newsletters

[Nature] The authors used single-cell and bulk RNA sequencing of clinical glioblastoma samples and samples from preclinical models, multiplexed immunofluorescence, in vivo CRISPR-based cell-specific genetic perturbations and in vitro mouse and human experimental systems to study the role of astrocytes in the immune response to glioblastoma.

[Molecular Neurodegeneration] The authors studied the genetic contribution of NIMA-related kinase 1 (NEK1) to ALS pathogenesis by analyzing the exome sequences of 920 Korean patients with ALS.

[Developmental Cell] Researchers identified a postsynaptic signaling complex comprising the G protein-coupled receptor- GPR158 and a constitutively active phospholipase C (PLC) family member, PLC X-domain containing 2 (PLCXD2), that controls spine apparatus abundance.

[Proceedings of The National Academy of Sciences of The United States of America] Scientists determined that stathmin-2 is required for functional recovery and reinnervation of neuromuscular junctions after sciatic nerve crush injury.

[Proceedings of The National Academy of Sciences of The United States of America] By recording from clock neurons, investigators established that physical activity leads to immediate activation of the neurons in the diurnal rodent, Arvicanthis.

[Nature Reviews Neuroscience] Scientists review recent insights from epigenomic, transcriptomic, and proteomic studies that advance the understanding of MECP2 as an interacting hub for DNA, RNA, and transcription factors, orchestrating diverse processes that are crucial for neuronal function.

[Brain] The authors delve into filamin A’s multifaceted role in neurodevelopment, with a particular focus on its contributions to neuronal migration, dendritic and axonal growth, and mechanotransduction.

[Brain Canada] Six exceptional research platforms located in Montreal have been awarded funding through Brain Canada's Platform Support Grants program.

[Development] Scientists characterized three small molecule and two cell contact-inducible systems for gene expression in and differentiation of mESCs.

[Scientific Reports] Researchers evaluated the effects of oxyresveratrol on human follicle dermal papilla cells and an androgenetic alopecia mouse model.

[Frontiers in Immunology] This prospective, observational, single-arm, single-center study assessed the efficacy and safety of bone marrow-derived MSCs for treating adult patients with biopsy-proven grade III-IV steroid-refractory acute graft-versus-host disease with predominant GI involvement.

[Hepatology] The authors explored the role of TATA-box binding protein associated factor 2 (TAF2) in HCC regulation using a hepatocyte-specific conditional knockout mouse, TAF2 knockdown and overexpressing human HCC cells, and TAF2 overexpression in mouse liver by hydrodynamic approach.