Newsletters
Molecular Mechanisms in Liver Repair and Regeneration: From Physiology to Therapeutics
[Signal Transduction and Targeted Therapy] The authors link molecular insights to therapeutic frontiers, systematically charting the trajectory from fundamental physiological mechanisms to innovative clinical applications in liver repair and regeneration.
Trajectory Analysis of Hepatic Stellate Cell Differentiation Reveals Metabolic Regulation of Cell Commitment and Fibrosis
[Nature Communications] Scientist explored the proteome trajectory of iPSCs differentiation to hepatic stellate cells (diHSCs) and identified retinoic acid related oprhan receptor alpha as a key transcription factor governing the metabolic reprogramming of hepatic stellate cells necessary for commitment, identity, and activation.
Targeting CDK4/6 in Breast Cancer
[Experimental & Molecular Medicine] The authors examine the molecular mechanisms regulating the cell cycle, current clinical applications of cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors in breast cancer, and key mechanisms contributing to drug resistance.
Melatonin and the Skin: Current Progress and Perspectives for Human Health
[Journal of Investigative Dermatology] Metabolic pathways, together with receptor- and nonreceptor-mediated phenotypic activities of its intermediates, have been identified as a cutaneous melatoninergic system. Pharmacological modulation of melatonin or its metabolites may be used to treat cutaneous disorders and aging.
Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives
[Stem Cell Research & Therapy] The authors summarize the connection between mitochondrial dysfunction and hair follicle development, outline the links between diseases related to mitochondrial disorders and hair issues, and highlight the influence of mitochondrial dysfunction on androgenetic alopecia.
Bristol Myers Angles Breyanzi for Another Blood Cancer As It Works to Close Gilead’s CAR-T Lead
With another trial win, Bristol Myers Squibb is touting Breyanzi as the CD19-directed CAR-T therapy with positive readouts in most cancer types. The latest...
Inhibition of Stemness and PD-L1 Expression by Pien Tze Huang Enhances T Cell-Mediated Killing of Colorectal Cancer
[Journal of Ethnopharmacology] Investigators assessed the impact of Pien Tze Huang on colorectal cancer stem cells (CSCs), and evaluate the coordination effect of PZH on T cell-mediated anti-colorectal cancer with patient-derived autologous T cell co-culture.
Hydrogel PCDME Creates Pancreatic Cancer Stem Cells in OXPHOS Metabolic State with TXNIP Elevation
[Biochemical and Biophysical Research Communications] Researchers demonstrated that hydrogel PCDME could rapidly induce pancreatic cancer cell spheroids with elevated levels of stem cell markers including Sox2, Oct3/4, and Nanog, and the growth rate was reduced.
The Molecular Impact of miR-326 in Acute Lymphoblastic Leukemia and Its Cross Talk with P53
[Annals of Hematology] Scientists revealed that miR-326 exhibited a multifunctional anti-tumor behavior, affecting various aspects of drug resistance, stemness, and apoptosis in cancer, particularly in the context of acute lymphoblastic leukemia.
CREB1-BCL2 Drives Mitochondrial Resilience in RAS GAP-Dependent Breast Cancer Chemoresistance
[Oncogene] Researchers showed that RASAL2 was enriched following neoadjuvant chemotherapy in triple-negative breast cancer patients. This enrichment was specific to the tumor compartment compared to adjacent normal tissues, suggesting that RASAL2 upregulation is tumor-selective.
Triethylamine-Mediated Protonation–Deprotonation Unlocks Dual-Drug Self Assembly to Suppress Breast Cancer Progression and Metastasis
[Proceedings of The National Academy of Sciences of The United States of America] Scientists emphasized the significant clinical potential of DT as an innovative carrier-free nanomedicine and provided profound insights into the design of nanomedicines for cancer therapy.
Exosome Platform with Three-in-One Functionality of mRNA Therapy, Immune Checkpoint Blockade, and Mild Photothermal Therapy for the Treatment of Triple-Negative Breast Cancer
[ACS Applied Materials & Interfaces] Investigators presented a multifunctional nanotherapeutic platform designed to combine cytokine-sensitized mild photothermal therapy, immune checkpoint blockade (ICB), and interleukin-2 mRNA therapy to reprogram the tumor microenvironment, thereby improving the efficacy of ICB therapy in TNBC.