Newsletters

[Cell Reports Medicine] Scientists demonstrated that poly-(ADP-ribose)-polymerase-11 (PARP11) is an essential regulator of immunosuppressive activities of tumor-infiltrating regulatory T cells.

[EMBO Molecular Medicine] To identify shared features associated to PD-1/LAG-3 dysfunctionality in human cancers and T cells, multiomic expression profiles were obtained for all TCGA cancers immune infiltrates.

[JCI Insight] Investigators identified a bacterial peptide that could be presented by HLA-B*27 to expanded public T cell receptors in the joint in axSpA and the eye in B27AAU.

[Brain Research Bulletin] The authors found that thymol treatment could ameliorate post-stroke neurological impairment and reduce infarct volume by mitigating microglial activation and pro-inflammatory response.

[Seminars In Cancer Biology] The authors summarize the phenotypic and functional features of exhaust and senescent T cells, and describes the key drivers of the two T cell dysfunctional states in the tumor microenvironment and their functional roles in ovarian cancer.

[Scientific Reports] Scientists conducted RNA sequencing of patient derived cutanoue squamous cell carcinoma (cSCC) cell lines and normal human epidermal keratinocytes and uncovered a novel set of lncRNAs implicated in cSCC cell locomotion.

[ACS Nano] Researchers developed a flexible sono–piezo patch that aimed to create an endogenous regenerative microenvironment to promote the repair of sweat glands in burn wounds. This patch utilized low-intensity pulsed ultrasound to activate electrical stimulation of the target tissue, resulting in enhanced pro-regenerative behaviors of niche tissues and cells, including peripheral nerves, fibroblasts, and vasculatures.

[Nature Immunology] Scientists reported that an intestinal T cell subset, derived from interleukin-17-producing helper T cells, induced the spontaneous transformation of the intestinal epithelium.

[Medical Oncology] The authors explore the various functions of exosomes in colorectal cancer and their potential as diagnostic markers, therapeutic targets, and drug delivery vehicles.

[The Lung Cancer Research Foundation (LCRF)] The LCRF, in collaboration with 23andMe Holding Co. and 20 lung cancer advocacy organizations, announced a new study to help advance research in lung cancer. The focus of the Lung Cancer Genetics Study is to better understand the genetics of people with lung cancer in order to improve detection, risk reduction, and care.

[AbbVie (BioSpace)] AbbVie announced that the European Commission has approved SKYRIZI® (risankizumab) for the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response to, lost response to, or were intolerant to conventional therapy or a biologic therapy.

[Brain] Researchers discovered that a neuron-specific loss of Bcl-2 family member BOK in Alzheimer’s disease patients and APPswe/PS1dE9 mice was closely associated with mitochondrial damage and mitophagy defects.