[Mucosal Immunology] Investigators review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based genes deletion and single cells transcriptomics.
[Life Science Alliance] Scientists found a higher HCC incidence in methamphetamine (METH) abusers. METH promoted cellular proliferation, migration, and invasion in two human-derived HCC cells.
Hepatic TNFRSF12A Promotes Bile Acid-Induced Hepatocyte Pyroptosis through NFκB/Caspase-1/GSDMD Signaling in Cholestasis
[Cell Death Discovery] Human hepatoma PLC/PRF/5-ASBT and THP1 cell lines or primary mouse hepatocytes were used for mechanistic studies. Hepatic TNFRSF12A expression was markedly increased in obstructive cholestasis or primary biliary cholangitis patients.
YAP1 Suppression Inhibits Autophagy and Improves the Efficacy of Anti-PD-1 Immunotherapy in Hepatocellular Carcinoma
[Experimental Cell Research] YAP1 expression and autophagy constituted positive feedback, in which YAP1 inhibition decreased the autophagy activity in liver tumor cells by hepatocyte-specific Yap1 knockout mice.
EGFR and Lyn Inhibition Augments Regorafenib Induced Cell Death in Sorafenib Resistant 3D Tumor Spheroid Model
[Cellular Signalling] Investigators utilized sorafenib resistant Huh7 cell line and LX2 hepatic stellate cell line to establish a sorafenib resistant 3D tumor spheroid model which could be used to test second-line treatment options.
[Oncology Reports] Scientists discuss the relationship of protein tyrosine phosphatases (PTPs) with inflammatory cytokines and chemotherapy/targeted drug resistance, providing detailed information on how PTPs can modulate inflammatory reactions and drug resistance to influence progression in HCC.
The Transcription Factor ATF3 Switches Cell Death from Apoptosis to Necroptosis in Hepatic Steatosis in Male Mice
[Nature Communications] The authors show that hepatic steatosis aggravation shifts the hepatocellular death mode from apoptosis to necroptosis, causing increased hepatocellular death.
Tuning the Corona-Core Ratio of Polyplex Micelles for Selective Oligonucleotide Delivery to Hepatocytes or Hepatic Immune Cells
[Biomaterials] Applying Raman-spectroscopy and dynamic in silico modeling on the polyplex micelles, researchers determined the corona-core ratio (CCR) and visualized the possible micellar structure with varying CCR.
[Medical Science Monitor] RNA-seq data from the Genotype-Tissue Expression Project and TCGA were analyzed in combination. In vitro cellular and molecular studies were conducted using SK-Hep-1 and Hep3B cells.
Experimental and Computational Studies of Silver(I) Dibenzoylmethane-Based Complexes, Interaction with DNA/RNA/BSA Biomolecules, and In Vitro Cytotoxic Activity
[Journal Of Inorganic Biochemistry] Ag(I) ion was found to be coordinated with the ligand's oxygens in almost a linear fashion in complex, while in complex it adopted a tetrahedral geometry.
[Damon Runyon Cancer Research Foundation] The Damon Runyon Cancer Research Foundation has announced its newest class of Damon Runyon Fellows, 14 exceptional postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.
Cullin-5 Deficiency Orchestrates the Tumor Microenvironment to Promote Mammary Tumor Development through CREB1-CCL2 Signaling
[Science Advances] Scientists used both the sleeping beauty transposon mutagenesis system and CRISPR-Cas9–mediated genome-wide screening in mice to identify potential genetic alterations that acted synergistically with breast cancer–associated gene 1 deficiency to promote tumorignesis.