Newsletters

DMC-BH Derivative DMC-GF Inhibits the Growth of Glioma Stem Cells by Targeting the TRIM33/SLC25A1/Mitochondrial Oxidative Phosphorylation Pathway

[Journal of Translational Medicine] Investigators developed DMC-GF, a novel GLUT1-based curcumin derivative, to enhance brain specificity and metabolic stability compared to its predecessor DMC-BH.

Clusterin-Mediated Polarization of M2 Macrophages: A Mechanism of Temozolomide Resistance in Glioblastoma Stem Cells

[Stem Cell Research & Therapy] Scientists investigated a novel resistance mechanism involving glioblastoma stem cells and the polarization of M2-type macrophages, mediated by the extracellular vesicle-based transfer of Clusterin.

Targeting the AKT/mTOR Pathway Attenuates the Metastatic Potential of Colorectal Carcinoma Circulating Tumor Cells in a Murine Xenotransplantation Model

[Molecular Oncology] The susceptibility of the colon cancer circulating tumor cell (CTC)-derived cell line CTC-MCC-41 to AKT and mammalian target of rapamycin (mTOR) inhibitors was evaluated.

Multi-Omic Analyses Reveal Aberrant DNA Methylation Patterns and the Associated Biomarkers of Nasopharyngeal Carcinoma and Its Cancer Stem Cells

[Scientific Reports] The authors integratively performed DNA methylome and transcriptome combined with single-nucleus RNA sequencing to investigate DNA methylation and gene expression patterns of nasopharyngeal carcinoma and CSCs.

Role of Octamer Transcription Factor 4 in Proliferation, Migration, Drug Sensitivity, and Stemness Maintenance of Pancreatic Cancer Cells

[World Journal of Clinical Oncology] Scientists investigated the role of Octamer transcription factor 4 in pancreatic CSCs and its effect on pancreatic cancer cell proliferation, migration, drug sensitivity, and stemness maintenance.

Role of Noncoding RNA As a Pacemaker in Cancer Stem Cell Regulation: A Review Article

[Journal of the Egyptian National Cancer Institute] The authors provide insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfully.

Windsor Hospital’S New Linear Accelerator Will Expand Cancer Treatment Capacity

[CBC News] A new machine at Windsor Regional Hospital could help deliver 26,000 more cancer treatments a year. The hospital's new linear accelerator is a new, state-of-the-art machine that delivers targeted radiation treatments to people with cancer.

TrkB Signaling Promotes Alveolar Capillary Angiogenesis Following Perinatal Hyperoxic Damage

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors determined whether TrkB signaling is required for perinatal general capillary cell proliferation and pulmonary angiogenesis in a hyperoxia mouse bronchopulmonary dysplasia model.

IL-6 Induces Mitochondrial ROS Production and Blunts NO Bioavailability in Human Aortic Endothelial Cells

[American Journal of Physiology-Regulatory Integrative and Comparative Physiology] Scientists tested the hypothesis that IL-6 induced mitochondrial reactive oxygen species (ROS) production and blunted nitric oxide (NO) bioavailability in endothelial cells.

Neoadjuvant BMS-813160, Nivolumab, Gemcitabine, and Nab-Paclitaxel for Patients with Pancreatic Cancer

[Clinical Cancer Research] Scientists conducted a Phase I/II single institution study combining chemotherapy gemcitabine and nab-paclitaxel, CCR2/5 inhibitor BMS-813160, and nivolumab for four 28-day cycles for patients with borderline resectable or locally advanced PDAC.

Genetic Protection from Type 1 Diabetes Resulting from Accelerated Insulin mRNA Decay

[Cell] Investigators discovered that the inositol-requiring enzyme 1α (IRE1α) digestion motif was present in insulin mRNA carrying SNP rs3842752. This SNP in the 3′ untranslated region of insulin gene associated with protection from T1D.

Microplastics Exacerbate Ferroptosis via Mitochondrial Reactive Oxygen Species-Mediated Autophagy in Chronic Obstructive Pulmonary Disease

[Autophagy] Researchers demonstrated that microplastics intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis in vitro and in vivo.
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