Role of Advanced Glycation End Products in Diabetic Vascular Injury: Molecular Mechanisms and Therapeutic Perspectives

[European Journal Of Medical Research] The authors discuss the formation and accumulation of advanced glycation end products and the subsequent activation of signaling pathways leading to oxidative stress, inflammation, endothelial dysfunction, smooth muscle cell proliferation, extracellular matrix remodeling, and impaired angiogenesis.

NIH Puts Hold on $30 Million Trial of Potential Stroke Drug

[Science] The NIH has paused the start of a major human trial of an experimental drug aimed at protecting the brain after a stroke and launched an investigation into recently aired concerns about the drug’s safety and whether lab studies supporting its promise contain manipulated images and data.

Platelet-Derived Apoptotic Vesicles Promote Bone Regeneration via Golgi Phosphoprotein 2 (GOLPH2)-AKT Signaling Axis

[ACS Nano] Investigators demonstrated that MSC-derived apoptotic vesicles (apoVs) were promising therapeutic agents for bone regeneration. However, clinical translation of MSC-derived apoVs had been hindered due to cell expansion and nuclear substance.

Enhancer-Mediated FOXO3 Expression Promotes MSC Adipogenic Differentiation by Activating Autophagy

[Biochimica Et Biophysica Acta-Molecular Basis Of Disease] Researchers identified enhancers-mediated gene FOXO3 promoting MSC adipogenic differentiation by activating autophagy.

Immunoregulatory Nanomedicine for Respiratory Infections

[Nature Reviews Bioengineering] Scientists discuss the design of nanovaccines, including lipid-nanocarrier-based messenger RNA nanovaccines, highlighting engineering strategies for different administration routes, including nasal administration.

The Neurobiology of SARS-CoV-2 Infection

[Nature Reviews Neuroscience] The authors put special emphasis on discussing the methodological difficulties of viral detection in central nervous system (CNS) tissue and discuss immune-based effects contributing to COVID-19-related CNS affection.

SARS-CoV-2 Spike Receptor-Binding Domain Is Internalized and Promotes Protein ISGylation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

[Scientific Reports] Researchers investigated the direct effects of spike receptor-binding domain on human cardiomyocytes differentiated from induced pluripotent stem cells.

Effectiveness of VSV Vectored SARS-CoV-2 Spike When Administered Through Intranasal, Intramuscular or a Combination of Both

[Scientific Reports] Scientists investigated the immunogenicity and efficacy of a prime-boost immunization regimen administered intranasally, intramuscularly, or combinations of the two.

Intracellular Tension Sensor Reveals Mechanical Anisotropy of the Actin Cytoskeleton

[Nature Communications] Researchers developed a molecular tension sensor that embeds into the F-actin cytoskeleton. Using this sensor, they measured tension within stress fibers and cortical actin, as the cell was subject to uniaxial stretch.

VEGFA mRNA-LNP Promotes Biliary Epithelial Cell-to-Hepatocyte Conversion in Acute and Chronic Liver Diseases and Reverses Steatosis and Fibrosis

[Communications Biology] Scientists showed in mice that hepatocyte proliferation is spatiotemporally regulated in each liver lobular zone during pregnancy, with transient proliferation of periportal and pericentral hepatocytes during mid and late gestation, respectively.

Hepatoprotective Effects of Aspirin on Diethylnitrosamine-Induced Hepatocellular Carcinoma in Rats by Reducing Inflammation Levels and PD-L1 Expression

[Scientific Reports] Researchers clarified whether aspirin exerted its anti-HCC effect by inhibiting PD-L1 expression. The rat model of HCC was established by drinking 0.01% diethylnitrosamine, and aspirin was given by gavage.

OMRF Scientist Awarded $3.4 Million to Investigate Immune Cells

[Oklahoma Medical Research Foundation] The National Institutes of Health recently awarded Dr. Xiao-Hong Sun a $3.4 million grant to continue unraveling mysteries about innate lymphoid cells, including whether they may offer clues about the differences in immune reactions between children and adults.