Newsletters

[Signal Transduction and Targeted Therapy] The authors discovered that during myocardial ischemia-reperfusion, double-stranded DNA-cyclic GMP-AMP synthase-stimulator of interferon genes (STING) signal accumulated, accompanied by high rates of myocardial ferroptosis.

[Lymphatic Research and Biology] Investigators characterized the transcriptional and translational responses of lymphatic endothelial cells during murine utaneous leishmaniasis using single-cell RNA sequencing data combined with flow cytometry and in vivo puromycin incorporation to assess translational activity.

[ACS Nano ] A strategy was proposed inspired by the “ant colony collaboration”, developing an “all-in-one” conformationally adaptive peptide nanoregulator through the intelligent integration of three functional peptides.

[Cell Reports] Comprehensive integration of RNA sequencing and ATAC sequencing revealed that ATF3 representing “Initiation_on” TF and ONECUT2 representing “Initiation_off” TF transiently modulate the occupancy of target promoters to license liver cells for regeneration.

[Molecular Therapy] To evaluate activity of NK-92/5.28.z cells against ErbB2-positive breast cancer, researchers developed an organoid model derived from CKP mice that allowed conditional activation of oncogenic driver mutations.

[Advanced Science] The authors explored the feasibility of achieving zonated organoid by co-culturing hESCs derived hepatocytes with hESCs derived liver sinusoidal endothelial cells (LSECs) exhibiting characteristics of either the liver lobule's pericentral or periportal regions.

[elife] The authors unveiled the detrimental effect of a high cholesterol diet on glucagon-like peptide-1 receptor (GLP-1R)-dependent glucoregulation in vivo, and the improvement in GLP-1R function that a reduction in cholesterol synthesis using simvastatin exerts in pancreatic islets.

[JCI Insight] In vitro experiments on mouse and human islets revealed that glycine and β-alanine, via GlyR activation, stimulated the proliferation of β cells and α cells, without affecting insulin or glucagon secretion.

[Science Advances] Investigators described methods to culture human large airway explants, small airway explants, and precision-cut lung slices for at least 14 days.

[npj Vaccines] Scientists investigated intratumoral delivery of three licensed viral vaccines— Shingrix, Gardasil-9, and Spikevax —in prevaccinated mice using the murine tumor model TC-1, which expressed HPV16 oncogenes E6 and E7.

[Journal of Cell Biology] Investigators identified novel crosstalk between depolarization-induced entry of Ca²⁺ and lysosomal cation release in maintaining dopaminergic neuronal function.

[Communications Biology] Researchers revealed that SEC14L3 expression was downregulated in HCC cells and tissues and correlated with advanced stages and poor prognosis.