[Nature News] A highly infectious and deadly strain of avian influenza virus has infected tens of millions of poultry birds across Europe, Asia, Africa and North America. But scientists are particularly concerned about the unprecedented spread in wild birds.
Screening of Organoids Derived from Patients with Breast Cancer Implicates the Repressor NCOR2 in Cytotoxic Stress Response and Antitumor Immunity
[Nature Cancer] High nuclear receptor corepressor 2 (NCOR2) in the tumors of patients with breast cancer predicted chemotherapy refractoriness, tumor recurrence and poor prognosis.
[Science of the Total Environment] By exposing human intestinal organoids to polystyrene nanoplastics with concentrations of 10 and 100 μg/mL, scientists presented evidence of their distinct accumulation in various type cells in intestinal organoids, then causing the cell apoptosis and inflammatory response.
[Nature] Investigators identified the protein Gibbin, encoded by the Xia–Gibbs AT-hook DNA-binding-motif-containing 1 disease gene7,8,9, as a key regulator of early epithelial morphogenesis.
Development of Human Pluripotent Stem Cell-Derived Hepatic Organoids as an Alternative Model for Drug Safety Assessment
[Biomaterials] Researchers generates human PSC-derived hepatic organoids (hHOs) with a high drug metabolic ability. They established a two-step protocol to produce hHOs from human pluripotent stem cells for long-term expansion and drug testing.
[Hepatology] Scientists discuss various historical aspects of 3D organoid culture, how it has been applied to the hepatobiliary system, and how organoid technology intersects with the emerging global field of liver regenerative medicine. We
[Cell and Tissue Research] When coupled with the ability to propagate prions in cells or organoids derived from stem cells, these next-generation cellular models should provide an ideal paradigm for identifying small molecules and other biological therapeutics capable of interfering with prion replication in animal and human prion disorders.
[North Carolina Agricultural and Technical State University] The creator of a mini-brain model used to study Alzheimer’s disease is the winner of the 2022 O. Max Gardner Award, the most prestigious annual prize for faculty awarded by the 17-campus University of North Carolina System.
Durable Discontinuation of Systemic Therapy in Patients Affected by Chronic Graft-versus-Host Disease
[Haematologica] Scientists evaluated the factors associated with durable systemic therapy (ST) discontinuation, defined as cessation of all ST for ≥12 months, using data from two prospectively followed cohorts from the chronic graft-versus-host disease Consortium.
Improved Trends in Survival and Engraftment after Single Cord Blood Transplantation for Adult Acute Myeloid Leukemia
[Blood Cancer Journal] To investigate the trends of survival and engraftment after cord blood transplantation (CBT) over the past 22 years, scientists retrospectively evaluated the data of patients with AML in Japan according to the time period of CBT.
Irisin and the Fibronectin Type III Domain-Containing Family: Structure, Signaling and Role in Female Reproduction
[Reproduction] The receptors for irisin are integrins, and it has recently been shown to alter steroidogenesis in ovarian granulosa cells although the effects appear to be species or context specific, and irisin may improve uterine and placental function in women and rodent models.