Regulatory T Cells Require IL6 Receptor Alpha Signaling to Control Skeletal Muscle Function and Regeneration

[Cell Metabolism] Using exercise and sarcopenia models, mice lacking IL6Rα on T cells demonstrated deficits in regulatory T cells, their functional maturation, and a more pronounced decline in muscle mass.

Oncometabolite D-2-Hydroxyglutarate—Dependent Metabolic Reprogramming Induces Skeletal Muscle Atrophy during Cancer Cachexia

[Communications Biology] Based on the up-regulation of catabolism and down-regulation of anabolism, researchers showed genetic mutation-mediated metabolic reprogramming in the progression of cancer cachexia by screening for metabolites and investigating their direct effect on muscle atrophy.

Myeloid-Derived Growth Factor Suppresses VSMC Dedifferentiation and Attenuates Postinjury Neointimal Formation in Rats by Activating S1PR2 and Its Downstream Signaling

[Acta Pharmacologica Sinica] Researchers investigated the effect of myeloid-derived growth factor to postinjury neointimal formation and the underlying mechanisms. Rat carotid arteries balloon-injured model was established.

Piezo Channels in Stretch Effects on Developing Human Airway Smooth Muscle

[American Journal Of Physiology-Lung Cellular And Molecular Physiology] Using 18-22-week gestation human fetal airway smooth muscle as an in vitro model, the authors tested the hypothesis that mechanosensitive Piezo channels contributed to stretch effects.

LKB1 Delays Atherosclerosis by Inhibiting Phenotypic Transformation of Vascular Smooth Muscle Cells

[International Journal Of Cardiology] ApoE−/− mice with vascular smooth muscle cells-specific overexpression of liver kinase B1 (LKB1) were constructed by adeno-associated virus transfection technique, and then fed with high-fat diet for eight weeks.

Muscle: An Independent Contributor to the Neuromuscular Spinal Muscular Atrophy Disease Phenotype

[JCI Insight] The authors discuss how survival motor neuron (SMN) might regulate the health of myofibers and their progenitors. They also speculate on therapeutic outcomes of failing to raise muscle SMN to healthful levels and present strategies to restore function to this tissue to ensure better treatment results.

Monash-Led National Program to Improve Treatments for Kids with Muscle Disease

[Monash University] A national clinical consortium has joined forces to improve care outcomes for children born with congenital muscle disease, led by Monash University’s Professor Peter Currie.

Engineered Bone Marrow as a Clinically Relevant Ex Vivo Model for Primary Bone Cancer Research and Drug Screening

[Proceedings Of The National Academy Of Sciences Of The United States Of America] The authors adapted a previously described engineered bone marrow construct for use as a three-dimensional platform to study how microenvironmental and immune factors affect osteosarcoma tumor progression.

δ-Tocotrienol Preconditioning Improves the Capability of Bone Marrow-Derived Mesenchymal Stem Cells in Promoting Wound Healing by Inhibiting BACH1-Related Ferroptosis

[Cell Death Discovery] Investigators explored the role of δ-Tocotrienol in bone marrow-derived MSC ability of wound healing. Transcriptome and single-cell analysis were used to explore the genes and pathways related to ferroptosis in wound tissues.

Therapeutic Potential of Oral-Derived Mesenchymal Stem Cells in Retinal Repair

[Stem Cell Reviews And Reports] Researchers comprehensively explored the potential of various types of stem cells from oral cavity as promising therapeutic options in retinal regeneration.

Adipose-Derived Mesenchymal Stem Cells -Conditioned Medium Effects on Glioma U87 Migration, Apoptosis, and Gene Expression

[Tissue and Cell] Using flow cytometry, adipose tissue-derived MSCs were identified, verified, and their conditioned media was used to treat U87 cells. Through RT-qPCR, scratch assay, and apoptosis analysis, scientists evaluated gene expression, cell migration, and apoptosis in U87 cells.

A CCL2+DPP4+ Subset of Mesenchymal Stem Cells Expedites Aberrant Formation of Creeping Fat in Humans

[Nature Communications] Investigators characterized creeping fat as pro-adipogenic and pro-fibrotic. Lipidomics analysis of Crohn’s disease patients and healthy controls revealed abnormal lipid metabolism in creeping fat.