Newsletters

[Journal of Translational Medicine] Investigators developed DMC-GF, a novel GLUT1-based curcumin derivative, to enhance brain specificity and metabolic stability compared to its predecessor DMC-BH.

[Stem Cell Research & Therapy] Scientists investigated a novel resistance mechanism involving glioblastoma stem cells and the polarization of M2-type macrophages, mediated by the extracellular vesicle-based transfer of Clusterin.

[Molecular Oncology] The susceptibility of the colon cancer circulating tumor cell (CTC)-derived cell line CTC-MCC-41 to AKT and mammalian target of rapamycin (mTOR) inhibitors was evaluated.

[Scientific Reports] The authors integratively performed DNA methylome and transcriptome combined with single-nucleus RNA sequencing to investigate DNA methylation and gene expression patterns of nasopharyngeal carcinoma and CSCs.

[World Journal of Clinical Oncology] Scientists investigated the role of Octamer transcription factor 4 in pancreatic CSCs and its effect on pancreatic cancer cell proliferation, migration, drug sensitivity, and stemness maintenance.

[Journal of the Egyptian National Cancer Institute] The authors provide insight into how noncoding RNAs regulate CSCs and how this correlation is manipulated to develop new therapies to eradicate cancer cells successfully.

[CBC News] A new machine at Windsor Regional Hospital could help deliver 26,000 more cancer treatments a year. The hospital's new linear accelerator is a new, state-of-the-art machine that delivers targeted radiation treatments to people with cancer.

[American Journal of Physiology-Lung Cellular and Molecular Physiology] The authors determined whether TrkB signaling is required for perinatal general capillary cell proliferation and pulmonary angiogenesis in a hyperoxia mouse bronchopulmonary dysplasia model.

[American Journal of Physiology-Regulatory Integrative and Comparative Physiology] Scientists tested the hypothesis that IL-6 induced mitochondrial reactive oxygen species (ROS) production and blunted nitric oxide (NO) bioavailability in endothelial cells.

[Clinical Cancer Research] Scientists conducted a Phase I/II single institution study combining chemotherapy gemcitabine and nab-paclitaxel, CCR2/5 inhibitor BMS-813160, and nivolumab for four 28-day cycles for patients with borderline resectable or locally advanced PDAC.

[Cell] Investigators discovered that the inositol-requiring enzyme 1α (IRE1α) digestion motif was present in insulin mRNA carrying SNP rs3842752. This SNP in the 3′ untranslated region of insulin gene associated with protection from T1D.

[Autophagy] Researchers demonstrated that microplastics intensified inflammation in COPD by enhancing autophagy-dependent ferroptosis in vitro and in vivo.