Stromal Notch Ligands Foster Lymphopenia-Driven Functional Plasticity and Homeostatic Proliferation of Naïve B Cells

In lymphopenic spleens, transferred B cells gradually lost their follicular phenotype and acquired characteristics of marginal zone B cells, as judged by cell surface phenotype, expression of integrins and chemokine receptors, positioning close to the marginal sinus, and an ability to rapidly generate functional plasma cells.