Rationally Screened and Designed ABCG2-Binding Aptamers for Targeting Cancer Stem Cells and Reversing Multidrug Resistance

ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) glycosylated extracellular region-binding aptamers were efficiently screened by a cladded molecularly imprinted polymer-based in vitro screening method and further rationally engineered into cyclic bivalent aptamers.