NewslettersImmunology of Infectious Disease NewsDisrupting Autorepression Circuitry Generates “Open-Loop Lethality” to Yield Escape-Resistant Antiviral AgentsBy lbeveridge - May 18, 20220153Researchers found that nucleic-acid decoys mimicking cis-regulatory sites acted as “feedback disruptors,” broke homeostasis, and increased viral transcription factors to cytotoxic levels (termed “open-loop lethality”).[Cell]Full Article