[Cells Tissues Organs] Scientists investigated the mechanism of miR-107 on sepsis-induced myocardial injury. Sepsis rat models were established by cecal ligation and puncture, and the cell model was established using lipopolysaccharide-induced cardiomyocytes.
[ACS Nano] Researchers developed a biosensing platform that was capable of performing on-chip and simultaneous measurement of contractility and electrophysiology of human induced pluripotent stem-cell-derived (iPSC) cardiomyocyte monolayers.
[Bioorganic & Medicinal Chemistry Letters] A new series of in vitro potent and highly selective histone methyl transferase enzyme G9a inhibitors was obtained. In particular, compound 2a, one the most potent G9a inhibitor identified, was endowed with >130-fold selectivity over GLP and excellent ligand efficiency.