Aberrant EVI1 Splicing Contributes to EVI1-Rearranged Leukemia
Scientists identified a novel, previously unannotated oncogenic RNA-splicing derived isoform of EVI1 which is frequently present in inv(3)/t(3;3) AML and directly contributes to leukemic transformation.
[Haematologica] Myeloid-derived suppressor cells (MDSCs) populations were evaluated in acquired aplastic anemia in which aberrant immune mechanisms contributed to bone marrow destruction.
[Cell Death & Disease] To investigate the effect of ellagic acid (EA) on benign prostate hyperplasia, scientists used EA, a phytochemical abundant in fruits and vegetables, to treat testosterone propionate-induced BPH rats and RWPE-1 human prostate epithelial cells.