Single-Cell RNA-Seq of a Soft-Tissue Sarcoma Model Reveals the Critical Role of Tumor-Expressed MIF in Shaping Macrophage Heterogeneity
Scientists employed single-cell RNA sequencing to characterize the immune composition of an undifferentiated pleiomorphic sarcoma mouse model, showing that macrophages in the sarcoma mass exhibit distinct activation states.
[Haematologica] Myeloid-derived suppressor cells (MDSCs) populations were evaluated in acquired aplastic anemia in which aberrant immune mechanisms contributed to bone marrow destruction.
[Cell Death & Disease] To investigate the effect of ellagic acid (EA) on benign prostate hyperplasia, scientists used EA, a phytochemical abundant in fruits and vegetables, to treat testosterone propionate-induced BPH rats and RWPE-1 human prostate epithelial cells.