Decoding Lymphomyeloid Divergence and Immune Hyporesponsiveness in G-CSF-Primed Human Bone Marrow by Single-Cell RNA-Seq

Through unbiased bioinformatics analysis, the authors showed the alterations in the transcriptional landscape of hematopoietic cells in granulocyte colony-stimulating factor (G-CSF)-primed bone marrow, and revealed that G-CSF-induced myeloid-biased differentiation initiated from the stage of lymphoid-primed multipotent progenitors.