Clonal Reconstruction from Co-Occurrence of Vector Integration Sites Accurately Quantifies Expanding Clones In Vivo

Tracing of integration sites (IS) leads to mis-quantification of the true clonal spectrum and limits safety considerations in gene therapies. Hence, scientists used correlations between repeated measurements of IS abundances to estimate their mutual similarity and identify clusters of co-occurring IS, for which they assume a clonal origin.
[Nature Communications]
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