Differentiation and Maturation Effect of All-Trans Retinoic Acid on Cultured Fetal RPE and Stem Cell-Derived RPE Cells for Cell-Based Therapy

Scientists investigated the culture-induced changes in passaged fetal retinal pigment epithelium (fRPE), hESC-RPE and hiPSC-RPE cells and explored the differentiation and maturation effect of all-trans retinoic acid on cells for manufacturing and screening high quality RPE cells for clinical transplantation.