PI3Kδ Activity Controls Plasticity and Discriminates between EMT and Stemness Based on Distinct TGFβ Signaling

Based on 3D organoid culture of hepatocellular carcinoma-derived cell lines and AAV8-based protein overexpression in the mouse liver, investigators showed that activity modulation of isoform δ of phosphoinositide 3-kinase (PI3Kδ) controls differentiation and discriminates between stemness.