Neuropeptide Y, a Paracrine Factor Secreted by Cancer Cells, Is an Independent Regulator of Angiogenesis in Colon Cancer

Orthotopic HT29 with intact vascular endothelial growth factor-A (VEGF-A) gene and VEGF-A knockdown HT29 colon cancer-bearing mice were treated with specific Y2 receptor antagonists, and the effects on angiogenesis and tumour growth were studied.