Rif1 Interacts with Non-canonical Polycomb Repressive Complex PRC1.6 to Regulate Mouse Embryonic Stem Cells Fate Potential

Researchers identified an unprecedented functional connection between Rif1 and the non-canonical polycomb repressive complex PRC1.6. Downregulation of the expression of either Rif1 or PRC1.6 subunits imposed similar impacts on the transcriptome of mESCs.