PIM3-AMPK-HDAC4/5 Axis Restricts MuERVL-Marked 2-Cell-Like State in Embryonic Stem Cells

Downregulation, deletion, or inhibition of PIM3 activated MuERVL, 2-cell genes, and trophectodermal genes in ESCs. By screening PIM3-regulated pathways, scientists discovered AMPK as its key target.