Subscribe
e.g. organoids

PIM3-AMPK-HDAC4/5 Axis Restricts MuERVL-Marked 2-Cell-Like State in Embryonic Stem Cells

Downregulation, deletion, or inhibition of PIM3 activated MuERVL, 2-cell genes, and trophectodermal genes in ESCs. By screening PIM3-regulated pathways, scientists discovered AMPK as its key target.
[Stem Cell Reports]
Full ArticleGraphical Abstract
Published In
NewslettersESC & iPSC News
spot_img

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News

An Ellagic Acid Coordinated Copper-Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness

[Small] Ellagic acid inhibited stemness maintenance by suppressing the hedgehog pathway, while Cu2+ further decreased stemness features of tumor cells by disrupting mitochondrial metabolism, effectively enhancing doxorubicin-mediated chemotherapy.
Cancer Stem Cell NewsNewsletters
Read more

Distinctive Mesenchymal-Like Neurofibroma Stem Cells Shape NF1 Clinical Phenotypes Controlled by BDNF Microenvironment

[Translational Oncology] Researchers determined the phenotypic and therapeutic relevance of tumor microenvironment in neurofibroma type I (NF1) patients. Tumor stem cell from NF1 were isolated and cultured using fluorescence activated cell sorting and colony formation experiments.
Cancer Stem Cell NewsNewsletters
Read more

METTL3 Facilitates Stemness Properties and Tumorigenicity of Cancer Stem Cells in Hepatocellular Carcinoma through the SOCS3/JAK2/STAT3 Signaling Pathway

[Cancer Gene Therapy] Loss- and gain-of-function experiments were utilized to assess the biological effects of METTL3 and SOCS3 on the proliferation and stemness phenotypes in vitro and in vivo.
Cancer Stem Cell NewsNewsletters
Read more
Brought to you by