Tissue- and Cell-Type-Specific Molecular and Functional Signatures of 16p11.2 Reciprocal Genomic Disorder Across Mouse Brain and Human Neuronal Models

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Researchers performed transcriptome profiling of 350 libraries from six tissues in mouse models harboring copy-number variants (CNVs) of the syntenic 7qF3 region, as well as cellular, transcriptional, and single-cell analyses in 54 isogenic neural stem cell, induced neuron, and cerebral organoid models of CRISPR-engineered 16p11.2 CNVs.
[American Journal of Human Genetics]
Abstract