Identification of the Polyether Ionophore Lenoremycin through a New Screening Strategy for Targeting Cancer Stem Cells

To identify candidate compounds targeting CSCs, investigators established a new screening strategy with colorectal CSC spheres and non-CSC spheres in a 3D culture system. Through chemical screening using their system with in-house microbial metabolite library, they identified polyether cation ionophores that selectively inhibited CSC sphere formation.