Tumor Factors Stimulate Lysosomal Degradation of Tumor Antigens and Undermine Their Cross-Presentation in Lung Cancer

Activities of dendritic cells that present tumor antigens are often suppressed in tumors. Scientists reported that this suppression was induced by tumor microenvironment-derived factors, which activate the activating transcription factor-3 transcription factor and downregulate cholesterol 25-hydroxylase.