Dusp6 Deficiency Attenuates Neutrophil-Mediated Cardiac Damage in the Acute Inflammatory Phase of Myocardial Infarction

Utilizing a rat strain harboring Dusp6 nonsense mutation and rat neutrophil-cardiomyocyte co-culture, researchers find that Dusp6 deficiency improved cardiac outcomes by predominantly attenuating neutrophil-mediated myocardial damage in acute inflammatory phase after myocardial infarction.