Newsletters

[British Journal of Cancer] Investigators presented and characterized a novel model derived from circulating tumour cells (CTCs) for understanding the plasticity and behaviour of CTCs and advanced breast cancer.

[Cell Death Discovery] Scientists isolated polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) from mouse breast cancer solid tumor tissues. In vitro co-culture experiments demonstrated that PMN-MDSCs increased the proportion of CD44hiCD24lo stem-like subpopulations in 4T1 cells, prompting non-stem cells to differentiate into stem cell-like cells.

[Cell Reports] By profiling 88,208 single-cell transcriptomes of circulating tumor cells (CTCs) matched with primary and metastatic lesions in breast cancer mouse models, scientists uncovered a striking enrichment of cell-cycle genes in CTCs, particularly in CTC clusters.

[Oncogene] Investigators reported the discovery of circPARPBP as a driver of chemoresistance; the elucidation of its mechanism through the recruitment of the SRCAP complex to activate CCL20 transcription and cancer stemness; and the demonstration that isoliquiritigenin suppresses this axis to overcome chemoresistance.

[Nature Communications] The authors demonstrated that leukemic stem cells exist in at least two different epigenomic states: a hematopoietic stem cell-or multipotent progenitor-like state that is sensitive to hypomethylating agents, independent of genetic mutations, or a lymphoid-primed multipotent progenitor-like nonresponder state.

[Scientific Reports] Researchers exposed CSC-enriched spheroids derived from HT-29 to a helium-based plasma jet for 30 to 240 seconds. They quantified cold atmospheric plasma (CAP)-induced hydrogen peroxide generation and assessed cell viability. Notably, CAP markedly suppressed self-renewal capacity.

[Scientific Reports] Scientists investigated the anticancer activity and molecular mechanism of ent-9α,11α-dihydroxy-15-oxo-kaur-16-en-19-oic acid (9α,11α-dihydroxy-kaurenoic acid), a natural kaurane-type diterpenoid isolated from Adenostemma lavenia, against mon-small cell lung cancer.

[University of Zurich ] Dr. Raphael Morscher from the University Children’s Hospital Zurich has received the Georg Friedrich Götz Award. He is being recognized for his research into a new therapeutic approach for neuroblastoma that targets the metabolism of cancer cells using a combination of drugs and dietary interventions.

[UT MD] In honor of their outstanding contributions to oncology, Drs. Sharon Giordano and Eduardo Vilar-Sanchez from University of Texas MD Anderson Cancer Center (UT MD) will receive special awards at the American Society of Clinical Oncology Annual Meeting.

[Discover Oncology] Recent studies indicate that leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) plays a crucial role in regulating tumor stem cell populations by modulating their self-renewal capabilities and regulating stem cell characteristics.

[Signal Transduction and Targeted Therapy] Researchers uncovered a bidirectional crosstalk between Oncostatin M receptor (OSMR) and tmCLIC1 in glioblastoma, essential for fueling its malignant growth.

[Cell Stem Cell] Scientists tested whether ferroptosis-related vulnerability contributes to the regulation of hippocampal neural precursor cells and their progeny.