Pentraxin 3 Regulates Tyrosine Kinase Inhibitor-Associated Cardiomyocyte Contraction and Mitochondrial Dysfunction via Erk/Jnk Signaling Pathways

Researchers assessed the therapeutic potential of pentraxin 3 inhibition on tyrosine kinase inhibitor-associated cardiotoxicity. They used a human embryonic stem cell line, RUES2, to generate cardiomyocyte cultures for functional testing.