CCN1 Upregulates IL-36 via AKT/NF-κB and ERK/CEBP β-Mediated Signaling Pathways in Psoriasis-Like Models

Investigators dissected the underlying molecular mechanism in imiquimod and interleukin(IL)-23-induced psoriasis-like models, and in primary normal human epidermal keratinocytes, that CCN1 could selectively induce the production of IL-36α and IL-36γ.