Restoration of WT1/miR-769-5p Axis by HDAC1 Inhibition Promotes MMT Reversal in Mesenchymal-Like Mesothelial Cells
Investigators characterized the molecular mechanism of the anti-fibrotic activity of histone deacetylase 1 (HDAC1) inhibition, focusing on the regulation of miRNAs previously described to exert an anti-fibrotic activity.
[Prostate Cancer Foundation] The Prostate Cancer Foundation announced four inaugural Class of 2022 TACTICAL Award recipients. This $30 million program will support cross-disciplinary pioneering research toward the goal of developing 21st Century therapies for the most life-threatening form of prostate cancer.
[Nature Communications] Researchers reported high levels of androgen receptor chromatin binding heterogeneity in human primary prostate tumors, that overlapped with heterogeneity observed in healthy prostate epithelium.