Agr2-Associated ER Stress Promotes Adherent-Invasive E. coli Dysbiosis and Triggers CD103⁺ Dendritic Cell IL-23-Dependent Ileocolitis

Investigators showed that ileal expression of AGR2 correlated with mucosal Enterobactericeae abundance in human inflammatory bowel disease and that Agr2 deletion leads to ER-stress-dependent expansion of mucosal-associated adherent-invasive Escherichia coli, which drives Th17 cell ileocolitis in mice.