Extracellular Matrix Stiffness Mediates Radiosensitivity in a 3D Nasopharyngeal Carcinoma Model
Researchers compared the tumor biological behaviors of nasopharyngeal carcinoma cells in 2D, on-surface 3D and embedded 3D systems, and investigated the correlation between radioresistance and ECM stiffness.
[Molecular Psychiatry] 1275 immune-related genes were curated and their expression changes investigated in 2467 postmortem brains of controls and patients with six major brain disorders, including schizophrenia, bipolar disorder, autism spectrum disorder, major depressive disorder, Alzheimer’s disease, and Parkinson’s disease.
[Signal Transduction and Targeted Therapy] Investigators systemically analyzed lung pathogenesis in SARS-CoV-2- and its delta variant-infected humanized CD147 transgenic mice. Histopathology and Transmission Electron Microscopy revealed inflammation, fibroblast expansion and pronounced fibrotic remodeling in SARS-CoV-2-infected lungs.