In Vivo Induction of Activin A-producing Alveolar Macrophages Supports the Progression of Lung Cell Carcinoma
Using an orthotopic murine lung cancer model and human carcinoma samples, investigators found that alveolar macrophages supported cancer cell proliferation and thus contributed to unfavourable outcomes.
[Mucosal Immunology] Investigators review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based genes deletion and single cells transcriptomics.
[Cell Death Discovery] Human hepatoma PLC/PRF/5-ASBT and THP1 cell lines or primary mouse hepatocytes were used for mechanistic studies. Hepatic TNFRSF12A expression was markedly increased in obstructive cholestasis or primary biliary cholangitis patients.