Implication of E3 Ligase RAD18 in UV-Induced Mutagenesis in Human Induced Pluripotent Stem Cells and Neuronal Progenitor Cells
Scientists employed Sup F assay for the measurement of mutation frequency after UV-C irradiation in iPSCs as PSC models and neural progenitor cells were derived from iPSCs as differentiated cells.
[British Journal of Cancer] The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.
[British Journal of Cancer] 582 mCRPC patients undergoing first-line abiraterone therapy from four institutions were sorted by three phases: discovery, training, and validation.
[International Journal of Radiation Oncology*Biology*Physics] Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.