A DLG1-ARHGAP31-CDC42 Axis Is Essential for the Intestinal Stem Cell Response to Fluctuating Niche Wnt Signaling

Investigators reported that Discs large 1, although dispensable for polarity and cellular turnover during intestinal homeostasis, was required for intestinal stem cell survival in the context of increased Wnt signaling.
[Cell Stem Cell]
AbstractGraphical Abstract

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