Caloric Restriction Delays Age-Related Muscle Atrophy by Inhibiting 11β−HSD1 to Promote the Differentiation of Muscle Stem Cells

Researchers used a calorie restriction (CR) model of elderly mice with muscle-specific 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) knockout mice and 11β-HSD1 overexpression mice to confirm that CR could delay muscle aging by inhibiting 11β-HSD1. The ability of self-proliferation and differentiation into muscle fibers of these mouse muscle stem cells was observed in vitro.