Antiangiogenic Activity of the Penicillin Derivative TAP7f in Melanoma

In a gel plug assay TAP7f blocked vascular formation induced by fibroblast growth factor 2. Furthermore, when murine B16-F10 melanoma cells pre-treated with TAP7f were injected intradermally in mice, investigators observed a decrease in the number and thickness of the capillaries surrounding the tumor.