Characterization of an Ablative Fractional CO₂ Laser-Induced Wound-Healing Model Based on In Vitro 3D Reconstructed Skin

A 3D full-thickness skin model was fabricated and treated with fractional ablativeCO2 laser. Wound-healing process was characterized by HE staining, noninvasive OCT imaging, immunostaining, as well as transepidermal water loss measurement.