Aging Alters the Cell Cycle Control and Mitogenic Signaling Responses of Human Hematopoietic Stem Cells
Investigators isolated highly HSC-enriched CD34+CD38-CD45RA-CD90+CD49f+ cells from cord blood and adult bone marrow and mobilized peripheral blood samples obtained from normal humans spanning seven decades of age.
[British Journal of Cancer] The immunoproteasome subunit LMP7 was silenced by using gene knockout or inhibited by the epoxyketone inhibitor ONX 0914 in a mouse castration-resistant prostate cancer (CRPC) tumor graft model and in interferon-γ-pretreated human CRPC cell lines in vitro.
[British Journal of Cancer] 582 mCRPC patients undergoing first-line abiraterone therapy from four institutions were sorted by three phases: discovery, training, and validation.
[International Journal of Radiation Oncology*Biology*Physics] Researchers performed an international multi-institutional retrospective study of 277 men with metachronous oligometastatic castration-sensitive prostate cancer who underwent targeted DNA sequencing of their primary/metastatic tumor.