Investigators review novel findings on the emerging role of mesenchymal cells in this process using insights gained from lineage tracing approaches, Cre-based genes deletion and single cells transcriptomics.
[Journal Of Experimental Medicine] Scientists showed that in pancreatic ductal adenocarcinomas (PDAC), proliferation of tumor-associated macrophagess could be driven by colony stimulating factor-1 produced by cancer-associated fibroblasts.
[Cancer Cell] Researchers examined the microenvironment in glioma and foundd that tumor-infiltrating T cells were mainly confined to the perivascular cuffs and expressed high levels of CCR5, CXCR3, and programmed cell death protein 1.
[Molecular Therapy Oncolytics] The authors demonstrated that the oncolytic virus, Coxsackievirus A21, could kill a range of B cell neoplasms, irrespective of an anti-viral interferon response.