Combining Ferroptosis Induction with MDSC Blockade Renders Primary Tumours and Metastases in Liver Sensitive to Immune Checkpoint Blockade

Glutathione peroxidase 4 was genetically altered in murine models for hepatocellular carcinoma and colorectal cancer (CRC) to analyze the effect of ferroptosis on tumour cells and the immune tumour microenvironment. Subcutaneously grown CRC organoids were utlilized, in cominbation with several other experimental methods.