SARS-CoV-2 Infection of Airway Organoids Reveals Conserved Use of Tetraspanin-8 by Ancestral, Delta, and Omicron Variants

Scientists biobanked airway organoids by preserving stem cell function, and then optimized viral infection with H1N1/PR8 and comprehensively characterized epithelial responses to SARS-CoV-2 infection in phenotypically stableairway organoids from 20 different subjects.