Immune Escape of Colorectal Tumors via Local LRH-1/Cyp11b1-Mediated Synthesis of Immunosuppressive Glucocorticoids

Scientists investigated the role of intestinal synthesis of glucocorticoids in the tumor development during inflammation-induced mouse model of colorectal cancer, using transplantation of glucocorticoid synthesis-proficient colorectal tumor organoids into immunocompetent recipient mice, and other experimental methods.