Newsletters

[Nature] Using a recombinant CcCoV receptor-binding domain (RBD) and a human receptor screening platform, scientists identified direct interactions with the human CEACAM proteins CEACAM3, CEACAM5, and CEACAM6.

[Signal Transduction and Targeted Therapy] Investigators revealed the dose-dependent manner and multi-faceted role of the male hormone testosterone in hamster model of COVID-19 by evaluations of manifestations including survival rate, body weight loss, viral load, immune responses, and lung injury.

[Nature] Scientists reported that mRNA–lipid nanoparticle vaccines do not require type 1 conventional dendritic (cDC) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but instead engage both cDC1 and cDC2 cells redundantly.

[Nature Reviews Immunology] The authors summarize how diverse lymphocyte-mediated immune responses drive the human disease spectrum seen following Leishmania infection.

[Nature] Ending malaria epidemics by 2030 is a target of the United Nations Sustainable Development Goals, but progress has clearly stalled.

[Hackensack Meridian Health (EurekAlert)] Hackensack Meridian Center for Discovery and Innovation (CDI)'s top non-tuberculous mycobacteria scientists, Drs. Véronique Dartois and Thomas Dick have developed new compounds which are now subject of a new collaboration and license agreement with BioVersys AG.

[EMBO Reports] The authors discuss how cytomegalovirus (CMV) manipulates myeloid immune cells to establish postnatal infection, particularly via the respiratory tract, and explore strategies by which CMVs breach the placental barrier and access the fetal brain.

[Montefiore Einstein] The Division of Allergy and Immunology at Children’s Hospital at Montefiore Einstein (CHAM) is set to advance crucial work that will improve health outcomes for people living with HIV through a $2.5 million grant to address factors that impact patients’ ability to manage their HIV care.

[Proceedings of the National Academy of Sciences of the United States of America] Using breast cancer and other cancer cell types in an experimental lung metastasis model, scientists showed that respiratory syncytial virus infection impairs tumor cell seeding and early growth in the lung, resulting in fewer metastatic nodules.

[Nature Communications] Researchers identified infrequent instances of SARS-CoV-2 infection in both villous and decidual tissues. Bulk and single-cell transcriptomic analyses revealed pronounced, cell type-specific antiviral and immune responses within the placental microenvironment.

[Iscience] In a cohort from Vancouver, Canada, researchers identified immune imprinting to endemic β-human coronaviruses along with an early expansion of memory B cells recognizing HKU1 and the conserved S2 domain following the first dose of ancestral-strain vaccination.

[Science Advances] Citarinostat increases histone crotonylation at the HIV long terminal repeat, robustly activating HIV transcription in cell lines, primary CD4+ T cells, and brain microglia from simian immunodeficiency virus–infected nonhuman primates and participants enrolled in the Last Gift rapid research autopsy cohort.