Targeting HDAC3 to Overcome the Resistance to ATRA or Arsenic in Acute Promyelocytic Leukemia through Ubiquitination and Degradation of PML-RARα

Researchers reported that histone deacetylase (HDAC) 3 was highly expressed in the acute promyelocytic leukemia subtype of AML, and the protein level of HDAC3 was positively associated with PML-RARα.