Targeting HDAC3 to Overcome the Resistance to ATRA or Arsenic in Acute Promyelocytic Leukemia through Ubiquitination and Degradation of PML-RARα

Researchers reported that histone deacetylase (HDAC) 3 was highly expressed in the acute promyelocytic leukemia subtype of AML, and the protein level of HDAC3 was positively associated with PML-RARα.
[Cell Death & Differentiation]

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