Tp53 Haploinsufficiency Is Involved in Hotspot Mutations and Cytoskeletal Remodeling in Gefitinib-Induced Drug-Resistant EGFR^L858R-Lung Cancer Mice

Investigators established in vivo animal models of gefitinib-induced drug-resistant lung cancer containing EGFRL858R and EGFRL858R*Tp53+/− mice to explore the molecular mechanisms of drug resistance by studying the genomic integrity and global gene expression.