Case Report: Immune Profiling Links Neutrophil and Plasmablast Dysregulation to Microvascular Damage in Post-COVID-19 Multisystem Inflammatory Syndrome in Adults (MIS-A)

Investigators used a deep phenotyping approach to examine immunologic responses in an individual with MIS-A. The findings revealed systemic inflammatory changes involving novel neutrophil and B-cell subsets, autoantibodies, complement, and hypercoagulability that are linked to systemic vascular dysfunction.