C4orf19 Inhibits Colorectal Cancer Cell Proliferation by Competitively Binding to Keap1 with TRIM25 via the USP17/Elk-1/CDK6 Axis
Exploration of the TCGA database indicated that C4orf19 was markedly downregulated in colorectal cancer (CRC) tissues in comparison to that observed in normal colonic tissues, suggesting its potential association with CRC behaviors.
[Signal Transduction and Targeted Therapy] Investigators showed that the oncogenic BCR-ABL1 of chronic myelogenous leukemia and the cellular ABL1 tyrosine kinases phosphorylated and inactivated Smad4 to block antiproliferative TGF-β signaling.
[Science of The Total Environment] RNA interference was performed to understand the function of astakine in hematopoiesis and apoptosis in Litopenaeus vannamei under ammonia-N exposure.
[Cell Reports] The authors integrated extensive longitudinal functional assessments of HSC-specific lineage tracing with single-cell transcriptome and epitope profiling.