N-methylsansalvamide Elicits Antitumor Effects in Colon Cancer Cells In Vitro and In Vivo by Regulating Proliferation, Apoptosis, and Metastatic Capacity

Scientists investigated the anti-colorectal cancer effect of N-methylsansalvamide (MSSV). MSSV exhibited the inhibition of the proliferation in HCT116 cells via induction of G0/G1 cell cycle arrest by downregulating CDK 2, CDK6, cyclin D, and cyclin E, and upregulating p21WAF1 and p27KIP1.