In Silico Analysis to Identify miR-1271-5p/PLCB4 (Phospholipase C Beta 4) Axis Mediated Oxaliplatin Resistance in Metastatic Colorectal Cancer

Researchers identified key regulatory genes and pathways associated with oxaliplatin (OXA) resistance. The Gene Expression Omnibus GSE42387 dataset containing gene expression profiles of parental and OXA-resistant LoVo cells was applied to explore potential targets.