Subscribe
e.g. organoids

FPR2 Shapes an Immune-Excluded Pancreatic Tumor Microenvironment and Drives T-Cell Exhaustion in a Sex-Dependent Manner

Single-cell RNA-sequencing and protein analyses uncovered a subpopulation of myeloid cells in pancreatic lesions associated with an immune‐excluded tumor phenotype and effector T-cell exhaustion exclusively in females.
[Cancer Research]
Full Article
Published In
NewslettersImmune Regulation News
spot_img

Stay up-to-date with your field!

Subscribe for free weekly science newsletters.

Related News

89bio’s Phase IIb ENLIVEN Trial of Pegozafermin in Nonalcoholic Steatohepatitis (NASH) Achieved High Statistical Significance on Both Primary Histology Endpoints with Weekly (QW) and...

[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
Hepatic Cell NewsNewsletters
Read more

LncRNA-MIAT Activates Hepatic Stellate Cells via Regulating Hippo Pathway and Epithelial-to-Mesenchymal Transition

[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.
Hepatic Cell NewsNewsletters
Read more

Targeting WDxR Motif Reprograms Immune Microenvironment and Inhibits Hepatocellular Carcinoma Progression

[EMBO Molecular Medicine] WD-repeat 6 (WDR6) deficiency in hepa1-6 cells drastically inhibited the growth and lung metastasis of orthotopically implanted tumors in immune-competent C57BL/6J mice.
Hepatic Cell NewsNewsletters
Read more
Brought to you by