Myeloid Cells from Langerhans Cell Histiocytosis Patients Exhibit Increased Vesicle Trafficking and an Altered Secretome Capable of Activating NK Cells

Scientists used an in vitro differentiation system and RNA-sequencing to compare monocyte-derived dendritic cells from Langerhans cell histiocytosis patients to those derived from healthy controls or patients with Crohn’s disease, a non-histiocytic inflammatory disease.