Isoform-Specific Knockdown of Long and Intermediate Prolactin Receptors Interferes with Evolution of B-Cell Neoplasms

In overt human B-cell malignancies, knockdown of the long plus intermediate isoforms of the PRL receptor (LF/IFPRLR) reduced B-cell viability and their MYC and BCL2 expression, and reduced the growth of human B-cell malignancies in vitro and in vivo.