Immunoglobulin G-Dependent Inhibition of Inflammatory Bone Remodeling Requires Pattern Recognition Receptor Dectin-1

Scientists studied immunoglobulin G (IgG)-dependent initiation of resolution of inflammation in cytokine- and autoantibody-driven models of rheumatoid arthritis and found pooled serum IgG sialylation inhibited joint inflammation, whereas inhibition of osteoclastogenesis was sialic acid independent.