A Mast Cell–Thermoregulatory Neuron Circuit Axis Regulates Hypothermia in Anaphylaxis

Researchers repored that the immunoglobin E/mast cell-mediated drop in body temperature in mice associated with anaphylaxis required the body’s thermoregulatory neural circuit, which was activated when granule-borne chymase from mast cells was deposited on proximal TRPV1+ sensory neurons and stimulated them via protease-activated receptor-1.